Structure-based design of prefusion-stabilized SARS-CoV-2 spikes - Hsieh, Ching-Lin; Goldsmith, Jory A.; Schaub, Jeffrey M.; DiVenere, Andrea M.; Kuo, Hung-Che; Javanmardi, Kamyab; Le, Kevin C.; Wrapp, Daniel; Lee, Alison G.; Liu, Yutong; Chou, Chia-Wei; Byrne, Patrick O.; et al. (Science (American Association for the Advancement of Science), 2020)
Keywords: Amino Acid Substitution; Antibodies; Betacoronavirus - chemistry; Biochem; Coronaviridae; Coronavirus Infections - prevention & control; Coronaviruses; COVID-19; COVID-19 Vaccines; Cryoelectron Microscopy; Freeze thaw cycles; Freeze-thaw durability; Freeze-thawing; Freezing; Heat stress; Heat tolerance; Humans; Pandemics; Proline; Proline - chemistry; Protein Domains; Protein Stability; Proteins; Respiratory diseases; Room temperature; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Vaccines; Viral diseases; Viral Vaccines - chemistry; Virology