Peroxisomes Contain a Specific Phytanoyl-CoA/Pristanoyl-CoA Thioesterase Acting as a Novel Auxiliary Enzyme in α- and β-Oxidation of Methyl-branched Fatty Acids in Mouse

• Published in: The Journal of biological chemistry Vol. 282; no. 37; pp. 26707 - 26716
• Main Authors: Westin, Maria A.K., Hunt, Mary C., Alexson, Stefan E.H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.09.2007
• Subjects: Animals; Base Sequence; Coenzyme A - metabolism; Fatty Acids - metabolism; Male; Medicin och hälsovetenskap; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidation-Reduction; Peroxisomes - enzymology; Phytanic Acid - analogs & derivatives; Phytanic Acid - metabolism; PPAR alpha - physiology; Thiolester Hydrolases - physiology

Phytanic acid and pristanic acid are derived from phytol, which enter the body via the diet. Phytanic acid contains a methyl group in position three and, therefore, cannot undergo β-oxidation directly but instead must first undergo α-oxidation to pristanic acid, which then enters β-oxidation. Both t...