Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 10; p. 999
• Main Authors: Panossian, Alexander, Abdelfatah, Sara, Efferth, Thomas
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 29.09.2021; MDPI
• Subjects: Animal cognition; Apoptosis; Cell division; Estrogens; Gene expression; ginsenoside Rg5; Human subjects; IPA pathways; Metabolites; Nervous system; network pharmacology; Physiology; red ginseng; Senescence; transcriptomics

Numerous in vitro studies on isolated cells have been conducted to uncover the molecular mechanisms of action of Panax ginseng Meyer root extracts and purified ginsenosides. However, the concentrations of ginsenosides and the extracts used in these studies were much higher than those detected in pha...