Effects of Different Adduct Ions, Ionization Temperatures, and Solvents on the Ion Mobility of Glycans

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 10; p. 2177
• Main Authors: Feng, Hao, Yamaguchi, Takumi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.05.2025; MDPI
• Subjects: Analysis; Carbohydrates; conformational dynamics; electrospray ionization; glycans; Ion Mobility Spectrometry; Ionization; Ions - chemistry; Mass Spectrometry; NMR; Nuclear magnetic resonance; Polysaccharides; Polysaccharides - chemistry; Scientific imaging; Sodium; Sodium - chemistry; Solvents; Solvents - chemistry; Temperature; Massachusetts; Japan; ion mobility spectrometry; mass spectrometry; glycans; electrospray ionization; conformational dynamics

The structural analysis of glycans remains a major challenge due to their high isomeric complexity and conformational flexibility arising from diverse glycosidic linkages and dynamic three-dimensional structures. Ion mobility–mass spectrometry (IM–MS) has been attracting attention as a way to develo...