Chlamydia cases in women of reproductive age, 2006–2020: an analysis of surveillance data from Southern China

• Published in: BMC public health Vol. 25; no. 1; pp. 158 - 8
• Main Authors: Zhao, Peizhen, Liang, Peng, Wang, Jinshen, Xu, Wenqian, Huang, Shujie, Wang, Cheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.01.2025; BioMed Central; BMC
• Subjects: Adolescent; Adult; Age; Age groups; Analysis; Care and treatment; China - epidemiology; Chlamydia; Chlamydia infections; Chlamydia Infections - epidemiology; Cities; Complications and side effects; Data analysis; Ethnicity; Family planning; Female; GDP; Gross Domestic Product; Health aspects; Humans; Incidence; Infections; Infectious diseases; Information systems; Marital status; Marriage; Mean; Middle Aged; Migration; Older people; Population; Population (statistical); Population density; Population Surveillance; Prevalence studies (Epidemiology); Prevention; Regression analysis; Regression models; Sex ratio; Sexually transmitted diseases; Sociodemographics; Software; Statistical analysis; Statistical models; STD; Surveillance; Trends; Women; Women of Reproductive Age; Womens health; Young Adult; China; Pearl River Delta; Guangdong China; Chlamydia; Surveillance; Women of Reproductive Age
• DOI: 10.1186/s12889-025-21318-1
• ISSN: 1471-2458

Chlamydia is common among women of reproductive age and can cause serious health issues. This study aimed to examine the trends and factors linked to newly diagnosed and reported chlamydia cases in women aged 15-49 in Guangdong Province from 2006 to 2020. We included all newly diagnosed and reported chlamydia cases from January 1, 2006, to December 31, 2020. Data from 21 cities in Guangdong Province were sourced from the National Notifiable Infectious Disease Reporting Information System in China. Temporal trends were analyzed using Joinpoint regression models. City-level factors (population density, net migration rate, and male-to-female sex ratio) were derived from the Guangdong Statistical Yearbook and the Guangdong Health and Family Planning Statistical Yearbook. Quasi-Poisson regression models were used to explore the relationship between sociodemographic factors and chlamydia incidence. From 2006 to 2020, 523,367 new chlamydia cases were reported among women of reproductive age in Guangdong. The mean reported rate was 122.6 per 100,000 population over 15 years, significantly increasing from 1.4 in 2006 to 179.7 in 2020 (average annual percent change [AAPC] = 47.4%, 95% CI: 42.8%-52.2%, P < 0.05). The highest rate was 196.8 per 100,000 population in 2019. Among older women, 9,045 cases were reported, with a mean reported rate of 4.9 per 100,000, rising significantly from 0.01 in 2006 to 9.6 in 2020 (AAPC = 52.6%, 95% CI: 30.3%-78.8%, P < 0.05). The reported rate among women of reproductive age correlated with the net migration rate (RR = 1.2; 95% CI: 1.2-1.3) and the ratio of those participating in child-bearing insurance to the permanent population (RR = 1.5; 95% CI: 1.4-1.6). The reported rate of new chlamydia cases among women of reproductive age was significantly higher than among older adults and increased markedly from 2006 to 2020. These findings underscore the urgent need for targeted prevention strategies for women of reproductive age.