Squaramide-Catalyzed Asymmetric Michael Addition/Cyclization Reaction for the Synthesis of Chiral Bisspiro Barbituric Acid–Oxindole Derivatives

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 9; p. 2000
• Main Authors: Qiao, De-Jun, Du, Da-Ming
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.04.2025; MDPI
• Subjects: Acids; asymmetric catalysis; barbituric acid; Biological activity; Catalysts; Drugs; Hydrocarbons; Michael addition; organocatalysis; oxindole; Solvents; Michael addition; organocatalysis; oxindole; asymmetric catalysis; barbituric acid

An efficient stereoselective strategy for the synthesis of chiral bisspiro barbituric acid–oxindole derivatives was developed. The asymmetric Michael addition/cyclization tandem reaction between benzylidene barbituric acids and oxindolylmalonitriles was catalyzed by squaramide catalyst, and the corr...