ANXA1-FPR2 axis mitigates the susceptibility to atrial fibrillation in obesity via rescuing AMPK activity in response to lipid overload

• Published in: Cardiovascular diabetology Vol. 23; no. 1; pp. 452 - 21
• Main Authors: Liu, Peng, Wang, Lu, Wang, Yixin, Jin, Linyan, Gong, Haoyu, Fan, Jiali, Zhang, Yudi, Li, Haiquan, Fu, Bowen, Wang, Qiaozhu, Fu, Yuping, Fan, Boyuan, Li, Xiaoli, Wang, Hongtao, Qin, Xinghua, Zheng, Qiangsun
• Format: Journal Article
• Language: English
• Published: England BioMed Central 21.12.2024; BMC
• Subjects: Algorithms; AMP-activated protein kinase; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Animals; Annexin A1 - genetics; Annexin A1 - metabolism; ANXA1-FPR2; Apoptosis; Apoptosis - drug effects; Arrhythmia; Atrial fibrillation; Atrial Fibrillation - enzymology; Atrial Fibrillation - genetics; Atrial Fibrillation - metabolism; Atrial Fibrillation - physiopathology; Atrial Fibrillation - prevention & control; Bioinformatics; Cardiac arrhythmia; Cardiomyocytes; Databases, Genetic; Datasets; Design of experiments; Diet, High-Fat; Disease Models, Animal; Fibrillation; Fibrosis; Gene expression; Glucose; High fat diet; Humans; Laboratory animals; Ligands; Lipid Metabolism; Lipids; Lipotoxicity; Male; Meta-analysis; Metabolic syndrome; Metabolism; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - enzymology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Obesity; Obesity - enzymology; Obesity - genetics; Obesity - metabolism; Oxidation; Oxidative stress; Oxidative Stress - drug effects; Palmitic acid; Palmitic Acid - pharmacology; Peptides; Performance evaluation; Proteins; Receptors, Formyl Peptide - genetics; Receptors, Formyl Peptide - metabolism; Receptors, Lipoxin - genetics; Receptors, Lipoxin - metabolism; Risk factors; Signal Transduction; Software; Susceptibility; Therapeutic targets; Transcriptomes; Weight control; ANXA1-FPR2; Obesity; AMP-activated protein kinase; Lipotoxicity; Atrial fibrillation

Atrial fibrillation (AF) is the most prevalent arrhythmia in clinical practice, and obesity serves as a significant risk factor for its development. The underlying mechanisms of obesity-related AF remain intricate and have yet to be fully elucidated. We have identified FPR2 as a potential hub gene i...