Chitosan-Silica Hybrid Biomaterials for Bone Tissue Engineering: A Comparative Study of Xerogels and Aerogels

• Published in: Gels Vol. 9; no. 5; p. 383
• Main Authors: Pérez-Moreno, Antonio, Piñero, Manuel, Fernández-Montesinos, Rafael, Pinaglia-Tobaruela, Gonzalo, Reyes-Peces, María V, Mesa-Díaz, María Del Mar, Vilches-Pérez, José Ignacio, Esquivias, Luis, de la Rosa-Fox, Nicolás, Salido, Mercedes
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 05.05.2023; MDPI
• Subjects: aerogel; Aerogels; bioactivity; Biocompatibility; Biodegradation; Biological activity; Biological products; Biomedical materials; Biopolymers; Bones; Calcium phosphates; Cell adhesion & migration; Cell culture; Cell differentiation; Chitosan; Comparative analysis; Comparative studies; Cytotoxicity; Differentiation (biology); Engineering research; Extracellular matrix; focal adhesion; Hydrogels; osteoconduction; Phosphates; Physical properties; Polyvinyl alcohol; Regeneration (physiology); Silica; Silicon dioxide; Sol-gel processes; Tissue engineering; Transmission Control Protocol/Internet Protocol (Computer network protocol); xerogel; Xerogels; Spain; focal adhesion; chitosan; bioactivity; mechanotransduction; bone healing; osteoconduction; xerogel; aerogel

Chitosan (CS) is a natural biopolymer that shows promise as a biomaterial for bone-tissue regeneration. However, because of their limited ability to induce cell differentiation and high degradation rate, among other drawbacks associated with its use, the creation of CS-based biomaterials remains a p...