Genome-wide association study of dilated cardiomyopathy-induced heart failure associated with renal insufficiency in a Chinese population

• Published in: BMC cardiovascular disorders Vol. 23; no. 1; pp. 335 - 13
• Main Authors: Hu, Yuexin, Jin, Liangli, Wang, Zhi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.06.2023; BioMed Central; BMC
• Subjects: Analysis; Beta blockers; Cardiomyopathy; Cardiomyopathy, Dilated; Cardiorenal syndrome; Cardiovascular disease; Care and treatment; Cohort analysis; Complications and side effects; Congenital diseases; Congestive heart failure; Development and progression; Dilated cardiomyopathy; Disease susceptibility; Ejection fraction; Gene frequency; Genes; Genetic aspects; Genetic testing; Genome-wide association studies; Genomes; Genotyping; Heart failure; Hypertension; Kidney failure; Medical diagnosis; Normal distribution; Prevention; Renal failure; Renal function; Renal insufficiency; Risk factors; Ryanodine receptors; Signal transduction; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statistical analysis; China; Heart failure; Cardiorenal syndrome; Renal insufficiency; Single-nucleotide polymorphisms; Dilated cardiomyopathy

As it is unclear whether there is genetic susceptibility to cardiorenal syndrome (CRS), we conducted a genome-wide association study of dilated cardiomyopathy (DCM)-induced heart failure (HF) associated with renal insufficiency (RI) in a Chinese population to identify putative susceptibility variant...