Development of an inactivated vaccine candidate for SARS-CoV-2

• Published in: Science (American Association for the Advancement of Science) Vol. 369; no. 6499; pp. 77 - 81
• Main Authors: Gao, Qiang, Bao, Linlin, Mao, Haiyan, Wang, Lin, Xu, Kangwei, Yang, Minnan, Li, Yajing, Zhu, Ling, Wang, Nan, Lv, Zhe, Gao, Hong, Ge, Xiaoqin, Kan, Biao, Hu, Yaling, Liu, Jiangning, Cai, Fang, Jiang, Deyu, Yin, Yanhui, Qin, Chengfeng, Li, Jing, Gong, Xuejie, Lou, Xiuyu, Shi, Wen, Wu, Dongdong, Zhang, Hengming, Zhu, Lang, Deng, Wei, Li, Yurong, Lu, Jinxing, Li, Changgui, Wang, Xiangxi, Yin, Weidong, Zhang, Yanjun, Qin, Chuan
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 03.07.2020; American Association for the Advancement of Science
• Subjects: Animals; Antibodies; Antibodies, Neutralizing - biosynthesis; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - biosynthesis; Antibodies, Viral - blood; Antibodies, Viral - immunology; Betacoronavirus - immunology; Betacoronavirus - isolation & purification; Chlorocebus aethiops; Coronaviridae; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; Coronaviruses; COVID-19; COVID-19 Vaccines; Dosage; Dose-Response Relationship, Immunologic; Female; Immunization; Immunogenicity, Vaccine; Immunoglobulin G - biosynthesis; Immunoglobulin G - blood; Immunoglobulin G - immunology; Infections; Macaca mulatta; Male; Medical research; Medicine; Mice; Mice, Inbred BALB C; Microbio; Monkeys; Neutralizing; Pandemics; Pandemics - prevention & control; Pharynx; Pilot Projects; Pneumonia, Viral - prevention & control; Pneumonia, Viral - virology; Primates; Public health; Rats; Rats, Wistar; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Strains (organisms); Vaccines; Vaccines, Inactivated - administration & dosage; Vaccines, Inactivated - adverse effects; Vaccines, Inactivated - immunology; Vero Cells; Viral diseases; Viral Load; Viral Vaccines - administration & dosage; Viral Vaccines - adverse effects; Viral Vaccines - immunology; Viruses

Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent race to develop a vaccine. Gao et al. report preclinical results of an early vaccine candidate called PiCoVacc, which protected rhesus macaque monkeys against SARS-CoV-2 infection when analyzed in shor...