High-flow nasal cannula oxygen therapy versus noninvasive ventilation for elderly chronic obstructive pulmonary disease patients after extubation: a noninferior randomized controlled trial protocol

• Published in: BMC pulmonary medicine Vol. 24; no. 1; pp. 539 - 9
• Main Authors: Yang, Xinyuan, Cheng, Jiangli, Wang, Zhen, Dong, Meiling, Xu, Zhaomin, Yu, He, Liang, Guopeng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.10.2024; BioMed Central; BMC
• Subjects: Adverse events; Age; Aged; Airway Extubation - adverse effects; Analgesics; Artificial respiration; Cannula; Care and treatment; Chronic obstructive pulmonary disease; Clinical trials; Comparative analysis; Consciousness; Demographic aspects; Dyspnea; Elderly; Extubation; Female; High-flow nasal cannula oxygen therapy; Humans; Humidity; Lung diseases; Lung diseases, Obstructive; Male; Methods; Noninvasive ventilation; Noninvasive Ventilation - methods; Oxygen equipment (Medical care); Oxygen Inhalation Therapy - methods; Oxygen therapy; Patient outcomes; Patients; Prospective Studies; Pulmonary Disease, Chronic Obstructive - therapy; Randomized Controlled Trials as Topic; Re-intubation; Respiratory failure; Study Protocol; Ventilation; Ventilators; Weaning; China; Re-intubation; High-flow nasal cannula oxygen therapy; Chronic obstructive pulmonary disease; Noninvasive ventilation; Elderly

Noninvasive ventilation (NIV) is widely used for sequential extubation in patients with chronic obstructive pulmonary disease (COPD). However, NIV may cause many adverse events such as claustrophobia, facial skin compression, air leakage, bloating, and even reflux aspiration, resulting in poor patie...