Geographical distribution of MTHFR C677T gene polymorphisms among the reproductive-age women in Chinese Han populations: based on migration

• Published in: BMC women's health Vol. 24; no. 1; pp. 407 - 9
• Main Authors: Shen, Yifen, Gu, Yongchun, Tang, Ying, Shen, Hao, Liu, Chao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18.07.2024; BioMed Central; BMC
• Subjects: Acids; Adult; Age; Alleles; Asian People - genetics; Asian People - statistics & numerical data; Birth defects; China - epidemiology; Chinese Han populations; Demographic aspects; East Asian People; Emigration and immigration; Enzymes; Equilibrium; Female; Folic acid; Gene Frequency; Genetic aspects; Genetic polymorphisms; Genotype; Genotype & phenotype; Geographical distribution; Health aspects; Health care; Homocysteine; Hospitals; Humans; Metabolism; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Migration; Oxidoreductases; Polymorphism; Polymorphism, Genetic - genetics; Polymorphism, Single Nucleotide - genetics; Population; Precision medicine; Pregnancy; Preventive medicine; Provinces; Risk assessment; Risk factors; Statistics; Vitamin B; Vitamin deficiency; Women patients; Womens health; Young Adult; China; United States > US; Geographical distribution; Methylenetetrahydrofolate reductase; Chinese Han populations; Migration; Polymorphism

Methylenetetrahydrofolate reductase (MTHFR) is essential for the metabolism of folic acid and homocysteine. The MTHFR C677T polymorphism is associated with several disorders. Our study aims to explore the geographical distributions of the MTHFR C677T polymorphism of women in China and how migration...