Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody - Rappazzo, C. Garrett; Tse, Longping V.; Kaku, Chengzi I.; Wrapp, Daniel; Sakharkar, Mrunal; Huang, Deli; Deveau, Laura M.; Yockachonis, Thomas J.; Herbert, Andrew S.; Battles, Michael B.; O’Brien, Cecilia M.; Brown, Michael E.; et al. (Science (American Association for the Advancement of Science), 2021)
Keywords: Affinity; Angiotensin-Converting Enzyme 2 - metabolism; Animal models; Animals; Antibodies; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - metabolism; Antibodies, Viral - genetics; Antibodies, Viral - immunology; Antibodies, Viral - metabolism; Antibody Affinity; Betacoronavirus - immunology; Binding Sites; Binding Sites, Antibody; Broadly Neutralizing Antibodies - genetics; Broadly Neutralizing Antibodies - immunology; Broadly Neutralizing Antibodies - metabolism; Cell Surface Display Techniques; Coronaviridae; Coronaviruses; COVID-19; COVID-19 - prevention & control; COVID-19 - therapy; COVID-19 Serotherapy; Directed evolution; Directed Molecular Evolution; Domains; Epitopes; Epitopes - immunology; Human populations; Humans; Immunization, Passive; Immunoglobulin Fc Fragments - immunology; Immunology; Lungs; Mice; Mice, Inbred BALB C; Microbio; Monoclonal antibodies; Neutralization; Pandemics; Progeny; Protein Domains; Protein Engineering; Receptors; Receptors, Coronavirus - metabolism; Respiratory diseases; SARS-CoV-2 - immunology; Severe Acute Respiratory Syndrome - immunology; Severe Acute Respiratory Syndrome - prevention & control; Severe Acute Respiratory Syndrome - therapy; Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus - immunology; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Viral diseases; Viruses; Yeast