GABA, glutamate and excitatory-inhibitory ratios measured using short-TE STEAM MRS at 7-Tesla: Effects of macromolecule basis sets and baseline parameters

• Published in: Heliyon Vol. 9; no. 7; p. e18357
• Main Authors: Okada, Tomohisa, Kuribayashi, Hideto, Urushibata, Yuta, Fujimoto, Koji, Akasaka, Thai, Seethamraju, Ravi Teja, Ahn, Sinyeob, Isa, Tadashi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2023; Elsevier
• Subjects: 7-Tesla; Excitatory-inhibitory ratio; Gamma-aminobutyric acid; Glutamate; glutamic acid; Magnetic resonance spectroscopy; magnetism; spectroscopy; Stimulated echo acquisition mode; Magnetic resonance spectroscopy; 7-Tesla; Gamma-aminobutyric acid; Excitatory-inhibitory ratio; Glutamate; Stimulated echo acquisition mode

Macromolecules (MMs) affect the precision and accuracy of neurochemical quantification in magnetic resonance spectroscopy. A measured MM basis is increasingly used in LCModel analysis combined with a spline baseline, whose stiffness is controlled by a parameter named DKNTMN. The effects of measured...