Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant

• Published in: Biological psychiatry (1969) Vol. 55; no. 10; pp. 1007 - 1012
• Main Authors: Bergström, Mats, Hargreaves, Richard J, Burns, H.Donald, Goldberg, Michael R, Sciberras, David, Reines, Scott A, Petty, Kevin J, Ögren, Mattias, Antoni, Gunnar, Långström, Bengt, Eskola, Olli, Scheinin, Mika, Solin, Olof, Majumdar, Anup K, Constanzer, Marvin L, Battisti, Wendy P, Bradstreet, Thomas E, Gargano, Cynthia, Hietala, Jarmo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.05.2004; Elsevier Science
• Subjects: Adult; Binding Sites; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Brain Mapping; depression; Dose-Response Relationship, Drug; Humans; Investigative techniques, diagnostic techniques (general aspects); Iodine Radioisotopes; Male; Medical sciences; Morpholines - blood; Morpholines - pharmacology; Nervous system; neurokinin 1 receptor (NK 1), aprepitant; Neurokinin-1 Receptor Antagonists; Radionuclide investigations; Receptors, Neurokinin-1 - chemistry; Receptors, Neurokinin-1 - metabolism; Single-Blind Method; Substance P; Tomography, Emission-Computed - methods; Substance P; neurokinin 1 receptor (NK 1), aprepitant; depression; Radionuclide study; Aprepitant; Human; NK1 Tachykinin receptor; Healthy subject; Vomiting; Central nervous system; Digestive diseases; Encephalon; Dose activity relation; Emission tomography

Aprepitant is a highly selective substance P (neurokinin 1 [NK 1] receptor) antagonist that significantly improves the pharmacotherapy of acute and delayed highly emetogenic chemotherapy–induced nausea and vomiting, probably through an action in the brain stem region of the central nervous system. H...