Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant - Bergström, Mats; Hargreaves, Richard J; Burns, H.Donald; Goldberg, Michael R; Sciberras, David; Reines, Scott A; Petty, Kevin J; Ögren, Mattias; Antoni, Gunnar; Långström, Bengt; Eskola, Olli; Scheinin, Mika; et al. (Biological psychiatry (1969), 2004)
Keywords: Adult; Binding Sites; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Brain Mapping; depression; Dose-Response Relationship, Drug; Humans; Investigative techniques, diagnostic techniques (general aspects); Iodine Radioisotopes; Male; Medical sciences; Morpholines - blood; Morpholines - pharmacology; Nervous system; neurokinin 1 receptor (NK 1), aprepitant; Neurokinin-1 Receptor Antagonists; Radionuclide investigations; Receptors, Neurokinin-1 - chemistry; Receptors, Neurokinin-1 - metabolism; Single-Blind Method; Substance P; Tomography, Emission-Computed - methods; Substance P; neurokinin 1 receptor (NK 1), aprepitant; depression; Radionuclide study; Aprepitant; Human; NK1 Tachykinin receptor; Healthy subject; Vomiting; Central nervous system; Digestive diseases; Encephalon; Dose activity relation; Emission tomography