An Open-Label Pilot Study Evaluating by Magnetic Resonance Imaging the Potential for a Disease-Modifying Effect of Celecoxib Compared to a Modelized Historical Control Cohort in the Treatment of Knee Osteoarthritis

• Published in: Seminars in arthritis and rheumatism Vol. 40; no. 3; pp. 185 - 192
• Main Authors: Raynauld, Jean-Pierre, Martel-Pelletier, Johanne, Beaulieu, André, Bessette, Louis, Morin, Frédéric, Choquette, Denis, Haraoui, Boulos, Abram, François, Pelletier, Jean-Pierre
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2010; Elsevier
• Subjects: Aged; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; cartilage loss; Cartilage, Articular - pathology; Celecoxib; Cohort Studies; cohort study; Cyclooxygenase 2 Inhibitors - adverse effects; Cyclooxygenase 2 Inhibitors - therapeutic use; Disease Progression; Diseases of the osteoarticular system; Dose-Response Relationship, Drug; Dyspepsia - chemically induced; Female; Heart Failure - chemically induced; Humans; Hypertension - chemically induced; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Miscellaneous. Osteoarticular involvement in other diseases; modelization; Osteoarthritis; Osteoarthritis, Knee - drug therapy; Osteoarthritis, Knee - pathology; Pharmacology. Drug treatments; Pilot Projects; Pyrazoles - adverse effects; Pyrazoles - therapeutic use; quantitative MRI; Rheumatology; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Treatment Outcome; BML; RCT; cohort study; CBC; MRI; NSAID; qMRI; quantitative MRI; COX; cartilage loss; OA; MCO; WOMAC; HC; modelization; BMI; magnetic resonance imaging; osteoarthritis; Western Ontario and McMaster Universities Osteoarthritis Index; quantitative magnetic resonance imaging; modelized historical cohort; celecoxib cohort; body mass index; cyclooxygenase; randomized controlled trial; bone marrow lesion; historical cohort; nonsteroidal anti-inflammatory drug; Knee; Knee osteoarthritis; Diseases of the osteoarticular system; Rheumatology; Celecoxib; Nuclear magnetic resonance imaging; Non steroidal antiinflammatory agent; Cartilage; Treatment; Cohort study; Arthropathy; Medical imagery; Degenerative disease; Osteoarthritis; Quantitative analysis

The aim of the study was to evaluate by quantitative magnetic resonance imaging the effect of celecoxib 200 mg daily on cartilage volume loss over 12 months in knee osteoarthritis. The primary outcome of this study was to evaluate cartilage volume loss in the medial compartment of the knee (femoral...