The human cytomegalovirus terminase complex as an antiviral target: a close-up view

• Published in: FEMS microbiology reviews Vol. 42; no. 2; pp. 137 - 145
• Main Authors: Ligat, G, Cazal, R, Hantz, S, Alain, S
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2018; Wiley-Blackwell
• Subjects: Antiviral agents; Antiviral Agents - administration & dosage; Antiviral Agents - pharmacology; Antiviral drugs; Clinical trials; Congenital defects; Cross-resistance; Cytomegalovirus; Cytomegalovirus - drug effects; Cytomegalovirus - enzymology; Cytomegalovirus Infections - drug therapy; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA structure; Drug Delivery Systems; Endodeoxyribonucleases - antagonists & inhibitors; Endodeoxyribonucleases - metabolism; Genomes; Life Sciences; Mammalian cells; Packaging; Phages; Replication; Review; Structure-function relationships; Terminase; Toxicity

Human cytomegalovirus (HCMV) is responsible for life-threatening infections in immunocompromised individuals and can cause serious congenital malformations. Available antivirals target the viral polymerase but are subject to cross-resistance and toxicity. New antivirals targeting other replication s...