Tocilizumab Induces IL-10-Mediated Immune Tolerance in Invasive Candidiasis

• Published in: Journal of fungi (Basel) Vol. 7; no. 8; p. 656
• Main Authors: Tan, Zhaohong, Mok, Michelle Meng Huang, Mar Soe, Win, Thamboo, Thomas Paulraj, Goh, Jessamine Geraldine, Sam, Qi Hui, Osato, Motomi, Ravikumar, Sharada, Chai, Louis Yi Ann
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 13.08.2021; MDPI
• Subjects: Candida albicans; Candidiasis; CD11b antigen; Complications; Cytokines; Dendritic cells; Experiments; Flow cytometry; Fungal infections; Immunological tolerance; Immunomodulation; Immunoregulation; Immunosuppressive agents; Inflammation; Interleukin 10; Interleukin 6; interleukin 6 blockade; Kidneys; Laboratory animals; Ligands; Lymphocytes T; Monoclonal antibodies; monoclonal antibody; Morbidity; Mortality; Transplants & implants; Tumor necrosis factor-TNF; Tumor necrosis factor-α; γ-Interferon; United States > US; Singapore

The existence of a hyperinflammatory state has been observed in patients with invasive fungal infections (IFI). It is being postulated whether morbidity from IFI may, in part, be a consequence of an unnecessarily prolonged or exaggerated proinflammatory immune response including interleukin 6 (IL-6)...