SARS-CoV-2 productively infects human gut enterocytes

• Published in: Science (American Association for the Advancement of Science) Vol. 369; no. 6499; pp. 50 - 54
• Main Authors: Lamers, Mart M., Beumer, Joep, van der Vaart, Jelte, Knoops, Kèvin, Puschhof, Jens, Breugem, Tim I., Ravelli, Raimond B. G., Paul van Schayck, J., Mykytyn, Anna Z., Duimel, Hans Q., van Donselaar, Elly, Riesebosch, Samra, Kuijpers, Helma J. H., Schipper, Debby, van de Wetering, Willine J., de Graaf, Miranda, Koopmans, Marion, Cuppen, Edwin, Peters, Peter J., Haagmans, Bart L., Clevers, Hans
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 03.07.2020; American Association for the Advancement of Science
• Subjects: ACE2; Angiotensin; Angiotensin-Converting Enzyme 2; Betacoronavirus - physiology; Betacoronavirus - ultrastructure; Biology; Cell Biol; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Cell Proliferation; Coronaviridae; Coronaviruses; COVID-19; Culture Media; Diarrhea; Digestive system; Disease transmission; Electron microscopy; Enterocytes; Enterocytes - metabolism; Enterocytes - ultrastructure; Enterocytes - virology; Epithelium; Gastrointestinal symptoms; Gastrointestinal tract; Gene Expression; Humans; Ileum - metabolism; Ileum - ultrastructure; Ileum - virology; Infectivity; Influenza; Intestine; Lung - virology; Male; Microbio; Organoids; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - genetics; Peptidyl-Dipeptidase A - metabolism; Receptors; Receptors, Virus - genetics; Receptors, Virus - metabolism; Respiratory diseases; Respiratory Mucosa - virology; RNA, Messenger - genetics; RNA, Messenger - metabolism; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus - physiology; Viral diseases; Virus Replication; Viruses; Vomiting
• ISSN: 0036-8075; 1095-9203; 1095-9203
• DOI: 10.1126/science.abc1669

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an influenza-like disease with a respiratory transmission route; however, patients often present with gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. Moreover, the virus has been detected in anal swabs, and...