Physiological Gingival Melanin Hyperpigmentation Treatment with Injectable Vitamin C and Scalpel Technique: A Randomised Controlled Clinical Trial

Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsur...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of dentistry Vol. 2023; pp. 4586923 - 8
Main Authors Chaudhary, Dhanashree S., Parwani, Simran R., Barkhade, Shital, Gajbhiye, Minal, Parwani, Rajkumar, Sikka, Geetanjali, Kawadkar, Kshipra, Soni, Nishita Jaju, Armogida, Niccolò Giuseppe, Dadlani, Himanshu, Spagnuolo, Gianrico
Format Journal Article
LanguageEnglish
Published Egypt Hindawi 2023
Hindawi Limited
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18–40 years conscious of dark gums were randomly allocated to test and control group by lottery method. Thorough Phase I therapy was performed one week before the procedure. Area and intensity of depigmentation were evaluated preoperatively and postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24 hrs, test group showed significantly lesser VAS score for pain as compared to control group. There was no statistically significant difference in preoperative area of pigmentation between the test and control group (p=0.936). Postoperatively also, there was no statistically significant difference in area of pigmentation between the test and control group (p=0.932). For comparing area of pigmentation, an independent t-test was applied and Mann–Whitney test was used for differentiating the intensity of pigmentation, repigmentation, and VAS score between the groups. The study concluded that Vitamin C mesotherapy and scalpel technique showed comparable results in reduction of areas and intensity of gingival hyperpigmentation.
AbstractList Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18–40 years conscious of dark gums were randomly allocated to test and control group by lottery method. Thorough Phase I therapy was performed one week before the procedure. Area and intensity of depigmentation were evaluated preoperatively and postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24 hrs, test group showed significantly lesser VAS score for pain as compared to control group. There was no statistically significant difference in preoperative area of pigmentation between the test and control group (p=0.936). Postoperatively also, there was no statistically significant difference in area of pigmentation between the test and control group (p=0.932). For comparing area of pigmentation, an independent t-test was applied and Mann–Whitney test was used for differentiating the intensity of pigmentation, repigmentation, and VAS score between the groups. The study concluded that Vitamin C mesotherapy and scalpel technique showed comparable results in reduction of areas and intensity of gingival hyperpigmentation.
Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18–40 years conscious of dark gums were randomly allocated to test and control group by lottery method. Thorough Phase I therapy was performed one week before the procedure. Area and intensity of depigmentation were evaluated preoperatively and postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24 hrs, test group showed significantly lesser VAS score for pain as compared to control group. There was no statistically significant difference in preoperative area of pigmentation between the test and control group ( p = 0.936 ). Postoperatively also, there was no statistically significant difference in area of pigmentation between the test and control group ( p = 0.932 ). For comparing area of pigmentation, an independent t-test was applied and Mann–Whitney test was used for differentiating the intensity of pigmentation, repigmentation, and VAS score between the groups. The study concluded that Vitamin C mesotherapy and scalpel technique showed comparable results in reduction of areas and intensity of gingival hyperpigmentation.
Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18-40 years conscious of dark gums were randomly allocated to test and control group by lottery method. Thorough Phase I therapy was performed one week before the procedure. Area and intensity of depigmentation were evaluated preoperatively and postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24 hrs, test group showed significantly lesser VAS score for pain as compared to control group. There was no statistically significant difference in preoperative area of pigmentation between the test and control group ( =0.936). Postoperatively also, there was no statistically significant difference in area of pigmentation between the test and control group ( =0.932). For comparing area of pigmentation, an independent -test was applied and Mann-Whitney test was used for differentiating the intensity of pigmentation, repigmentation, and VAS score between the groups. The study concluded that Vitamin C mesotherapy and scalpel technique showed comparable results in reduction of areas and intensity of gingival hyperpigmentation.
Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18–40 years conscious of dark gums were randomly allocated to test and control group by lottery method. Thorough Phase I therapy was performed one week before the procedure. Area and intensity of depigmentation were evaluated preoperatively and postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24 hrs, test group showed significantly lesser VAS score for pain as compared to control group. There was no statistically significant difference in preoperative area of pigmentation between the test and control group ( p =0.936). Postoperatively also, there was no statistically significant difference in area of pigmentation between the test and control group ( p =0.932). For comparing area of pigmentation, an independent t -test was applied and Mann–Whitney test was used for differentiating the intensity of pigmentation, repigmentation, and VAS score between the groups. The study concluded that Vitamin C mesotherapy and scalpel technique showed comparable results in reduction of areas and intensity of gingival hyperpigmentation.
Author Barkhade, Shital
Parwani, Simran R.
Gajbhiye, Minal
Parwani, Rajkumar
Kawadkar, Kshipra
Soni, Nishita Jaju
Spagnuolo, Gianrico
Armogida, Niccolò Giuseppe
Sikka, Geetanjali
Chaudhary, Dhanashree S.
Dadlani, Himanshu
AuthorAffiliation 1 Department of Periodontology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra 444602, India
3 Department of Periodontology, Eklavya Dental College & Hospital Kotpulti, Rajasthan 303108, India
7 Therapeutic Dentistry Department, Institute for Dentistry, Sechenov University, Moscow 119991, Russia
4 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples 80131, Italy
2 Department of Oral Pathology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra 444602, India
5 Department of Periodontology, Kalka Dental College, Meerut 250002, India
6 Kalka Dental College, Meerut 250016, India
AuthorAffiliation_xml – name: 5 Department of Periodontology, Kalka Dental College, Meerut 250002, India
– name: 6 Kalka Dental College, Meerut 250016, India
– name: 3 Department of Periodontology, Eklavya Dental College & Hospital Kotpulti, Rajasthan 303108, India
– name: 4 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples 80131, Italy
– name: 7 Therapeutic Dentistry Department, Institute for Dentistry, Sechenov University, Moscow 119991, Russia
– name: 1 Department of Periodontology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra 444602, India
– name: 2 Department of Oral Pathology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra 444602, India
Author_xml – sequence: 1
  givenname: Dhanashree S.
  orcidid: 0000-0002-8696-2838
  surname: Chaudhary
  fullname: Chaudhary, Dhanashree S.
  organization: Department of Periodontology V.Y.W.S. Dental College and Hospital Amravati Maharashtra 444602 India dchamt.com
– sequence: 2
  givenname: Simran R.
  orcidid: 0000-0002-5861-6049
  surname: Parwani
  fullname: Parwani, Simran R.
  organization: Department of Periodontology V.Y.W.S. Dental College and Hospital Amravati Maharashtra 444602 India dchamt.com
– sequence: 3
  givenname: Shital
  surname: Barkhade
  fullname: Barkhade, Shital
  organization: Department of Periodontology V.Y.W.S. Dental College and Hospital Amravati Maharashtra 444602 India dchamt.com
– sequence: 4
  givenname: Minal
  surname: Gajbhiye
  fullname: Gajbhiye, Minal
  organization: Department of Periodontology V.Y.W.S. Dental College and Hospital Amravati Maharashtra 444602 India dchamt.com
– sequence: 5
  givenname: Rajkumar
  orcidid: 0000-0001-8974-5698
  surname: Parwani
  fullname: Parwani, Rajkumar
  organization: Department of Oral Pathology V.Y.W.S. Dental College and Hospital Amravati Maharashtra 444602 India dchamt.com
– sequence: 6
  givenname: Geetanjali
  orcidid: 0000-0002-7648-4262
  surname: Sikka
  fullname: Sikka, Geetanjali
  organization: Department of Periodontology Eklavya Dental College & Hospital Kotpulti Rajasthan 303108 India
– sequence: 7
  givenname: Kshipra
  orcidid: 0000-0002-3565-929X
  surname: Kawadkar
  fullname: Kawadkar, Kshipra
  organization: Department of Periodontology V.Y.W.S. Dental College and Hospital Amravati Maharashtra 444602 India dchamt.com
– sequence: 8
  givenname: Nishita Jaju
  surname: Soni
  fullname: Soni, Nishita Jaju
  organization: Department of Periodontology V.Y.W.S. Dental College and Hospital Amravati Maharashtra 444602 India dchamt.com
– sequence: 9
  givenname: Niccolò Giuseppe
  orcidid: 0000-0002-3259-3045
  surname: Armogida
  fullname: Armogida, Niccolò Giuseppe
  organization: Department of Neurosciences Reproductive and Odontostomatological Sciences University of Naples Federico II Naples 80131 Italy unina.it
– sequence: 10
  givenname: Himanshu
  orcidid: 0000-0002-7354-1962
  surname: Dadlani
  fullname: Dadlani, Himanshu
  organization: Department of Periodontology Kalka Dental College Meerut 250002 India collegedunia.com
– sequence: 11
  givenname: Gianrico
  orcidid: 0000-0003-3769-9786
  surname: Spagnuolo
  fullname: Spagnuolo, Gianrico
  organization: Department of Neurosciences Reproductive and Odontostomatological Sciences University of Naples Federico II Naples 80131 Italy unina.it
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37252615$$D View this record in MEDLINE/PubMed
BookMark eNp9kk1vEzEQhleoiJbSG2dkiQsShHrs9cdyQVUEbaQiEASuluOdTRw5dvBuWuVv8ItxmlBRDvjisefxO_breVodxRSxqp4DfQsgxDmjjJ_XQsuG8UfVCUitRlpxeXQfM31cnfX9kpbBoRYgn1THXDHBJIiT6teXxbb3KaS5dzaQSx_n_qYEnzDY6CO52q4xr_18hXGwg0-RTDPaYbckt35YkElcohvsLCD54Qe7KmfGxMaWfCt6awxkim4R_c8NviMX5GvJpJXvsSXjFIecQtiFwce78tPsbXhWPe5s6PHsMJ9W3z9-mI6vRtefLyfji-uREyCGkXCNBahdo6XSKMAx7hAaKVG5jiuoG1mAzrWUoRS0pqyw0NYcqLTgZvy0mux122SXZp39yuatSdabu42U58bmwbuAhvMZ1x1ygQprqKlWs1K-ZRo7rWtti9b7vdZ6M1th64o92YYHog8z0S_MPN0YoAyYVKIovDoo5FTM6gdTbHIYyjdg2vSGaUYbBcB1QV_-gy7TJsfiVaGg0Y1UFAr1Zk-5nPo-Y3d_G6Bm1zxm1zzm0DwFf_H3C-7hP61SgNd7YOFja2_9_-V-AxvazpE
CitedBy_id crossref_primary_10_7759_cureus_48417
crossref_primary_10_3390_jcm12206567
crossref_primary_10_7759_cureus_56511
crossref_primary_10_1186_s12903_024_04345_z
crossref_primary_10_1186_s12903_023_03614_7
crossref_primary_10_7759_cureus_58285
Cites_doi 10.5005/jp-journals-10026-1127
10.1186/1746-160x-10-8
10.4103/0972-124x.138699
10.1371/journal.pone.0091947
10.1111/j.1600-0765.2007.00977.x
10.4103/0976-237x.152964
10.1016/j.yclnex.2018.12.003
10.1902/jop.2015.140394
10.1034/j.1600-0625.12.s2.1.x
10.4103/0974-2077.99458
10.1902/jop.1999.70.9.1077
10.1002/jcp.24012
10.1111/j.1600-0749.1998.tb00708.x
10.1016/j.jobcr.2022.05.015
10.4172/2161-1122.1000417
10.1007/s00784-021-03843-6
10.1902/jop.2009.080409
10.1111/j.1600-051x.2009.01422.x
10.18632/oncotarget.14887
10.3390/microorganisms9061218
10.3390/dj11010002
10.4103/0972-124x.142450
10.1136/bcr-2014-208559
10.1051/mmnp/20105101
10.1111/j.1755-148x.2008.00506.x
10.1016/0030-4220(63)90299-8
10.1001/archderm.1957.01550140112021
ContentType Journal Article
Copyright Copyright © 2023 Dhanashree S. Chaudhary et al.
Copyright © 2023 Dhanashree S. Chaudhary et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
Copyright © 2023 Dhanashree S. Chaudhary et al. 2023
Copyright_xml – notice: Copyright © 2023 Dhanashree S. Chaudhary et al.
– notice: Copyright © 2023 Dhanashree S. Chaudhary et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
– notice: Copyright © 2023 Dhanashree S. Chaudhary et al. 2023
DBID RHU
RHW
RHX
NPM
AAYXX
CITATION
3V.
7QP
7X7
7XB
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
CWDGH
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1155/2023/4586923
DatabaseName Hindawi Publishing Complete
Hindawi Publishing Subscription Journals
Open Access: Hindawi Publishing
PubMed
CrossRef
ProQuest Central (Corporate)
Calcium & Calcified Tissue Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
Middle East & Africa Database
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
Health & Medical Collection (Alumni Edition)
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle PubMed
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Middle East & Africa Database
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

CrossRef
PubMed
Publicly Available Content Database

Database_xml – sequence: 1
  dbid: RHX
  name: Open Access Journals (Hindawi Publishing)
  url: http://www.hindawi.com/journals/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: Open Access: DOAJ - Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Dentistry
EISSN 1687-8736
Editor Tatakis, Dimitris N.
Editor_xml – sequence: 1
  givenname: Dimitris N.
  surname: Tatakis
  fullname: Tatakis, Dimitris N.
– fullname: Dimitris N Tatakis
EndPage 8
ExternalDocumentID oai_doaj_org_article_33b38fe35e7e414087b5c9d28ef8848a
10_1155_2023_4586923
37252615
Genre Journal Article
GroupedDBID 188
29J
2WC
34H
3V.
4.4
53G
5VS
7X7
8FE
8FH
8FI
8FJ
AAFWJ
AAJEY
ABUWG
ACPRK
ADBBV
ADRAZ
AFKRA
AFPKN
AHMBA
AINHJ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CWDGH
DIK
E3Z
EBS
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IEA
IHR
KQ8
LK8
M48
M7P
O5R
OK1
PIMPY
PQQKQ
PROAC
RHU
RHW
RHX
RNS
RPM
TR2
UKHRP
24P
2UF
ALIPV
C1A
CEFSP
CNMHZ
EJD
H13
IL9
ITC
NPM
O5S
PGMZT
UZ5
AAYXX
CITATION
7QP
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PQEST
PQUKI
PRINS
7X8
5PM
ID FETCH-LOGICAL-c515t-5c9a114c98678e51c23ce1966e7cf3714969a1fcd02e6504024c91d43106a1cb3
IEDL.DBID RPM
ISSN 1687-8728
IngestDate Mon Oct 07 19:36:18 EDT 2024
Tue Sep 17 21:31:36 EDT 2024
Fri Aug 16 21:02:24 EDT 2024
Thu Oct 10 22:22:58 EDT 2024
Fri Aug 23 02:09:23 EDT 2024
Sat Sep 28 08:16:49 EDT 2024
Sun Jun 02 19:23:10 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Language English
License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2023 Dhanashree S. Chaudhary et al.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c515t-5c9a114c98678e51c23ce1966e7cf3714969a1fcd02e6504024c91d43106a1cb3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Dimitris N. Tatakis
ORCID 0000-0002-3565-929X
0000-0002-7648-4262
0000-0002-3259-3045
0000-0002-5861-6049
0000-0001-8974-5698
0000-0003-3769-9786
0000-0002-8696-2838
0000-0002-7354-1962
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212675/
PMID 37252615
PQID 2819896701
PQPubID 237272
PageCount 8
ParticipantIDs doaj_primary_oai_doaj_org_article_33b38fe35e7e414087b5c9d28ef8848a
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10212675
proquest_miscellaneous_2820971138
proquest_journals_2819896701
crossref_primary_10_1155_2023_4586923
pubmed_primary_37252615
hindawi_primary_10_1155_2023_4586923
PublicationCentury 2000
PublicationDate 2023-00-00
PublicationDateYYYYMMDD 2023-01-01
PublicationDate_xml – year: 2023
  text: 2023-00-00
PublicationDecade 2020
PublicationPlace Egypt
PublicationPlace_xml – name: Egypt
– name: New York
PublicationTitle International journal of dentistry
PublicationTitleAlternate Int J Dent
PublicationYear 2023
Publisher Hindawi
Hindawi Limited
Publisher_xml – name: Hindawi
– name: Hindawi Limited
References 22
24
25
26
K. A. Kadri (23) 2021; 12
27
28
29
S. T. Narendra (1) 2017; 3
30
M. Oringer (20) 1975
31
10
32
11
12
13
14
15
17
18
19
M. G. Newman (2) 2006
3
4
5
6
7
8
9
N. M. Yussif (16) 2016; 8
21
References_xml – ident: 21
  doi: 10.5005/jp-journals-10026-1127
– ident: 5
  doi: 10.1186/1746-160x-10-8
– ident: 31
  doi: 10.4103/0972-124x.138699
– volume: 3
  start-page: 36
  year: 2017
  ident: 1
  article-title: Comparative evaluation of effectiveness of LASER with electrosurgery for the management of gingival hyperpigmentation
  publication-title: Int J Oral Health Med Res
  contributor:
    fullname: S. T. Narendra
– ident: 27
  doi: 10.1371/journal.pone.0091947
– ident: 18
  doi: 10.1111/j.1600-0765.2007.00977.x
– ident: 13
  doi: 10.4103/0976-237x.152964
– ident: 3
  doi: 10.1016/j.yclnex.2018.12.003
– ident: 29
  doi: 10.1902/jop.2015.140394
– ident: 6
  doi: 10.1034/j.1600-0625.12.s2.1.x
– volume-title: Electrosurgery in Dentistry
  year: 1975
  ident: 20
  contributor:
    fullname: M. Oringer
– ident: 28
  doi: 10.4103/0974-2077.99458
– ident: 32
  doi: 10.1902/jop.1999.70.9.1077
– ident: 19
  doi: 10.1002/jcp.24012
– ident: 7
  doi: 10.1111/j.1600-0749.1998.tb00708.x
– ident: 11
  doi: 10.1016/j.jobcr.2022.05.015
– ident: 17
  doi: 10.4172/2161-1122.1000417
– ident: 10
  doi: 10.1007/s00784-021-03843-6
– ident: 15
  doi: 10.1902/jop.2009.080409
– ident: 30
  doi: 10.1111/j.1600-051x.2009.01422.x
– volume: 12
  start-page: 43062
  year: 2021
  ident: 23
  article-title: Evaluation of injectable vitamin c as a depigmenting agent in physiological gingival melanin hyperpigmentation: an analytical study
  publication-title: Int. J. Recent Sci. Res
  contributor:
    fullname: K. A. Kadri
– volume: 8
  start-page: 113
  year: 2016
  ident: 16
  article-title: Evaluation of injectable Vitamin C as a depigmenting agent in physiologic gingival melanin hyperpigmentation: a clinical trial
  publication-title: Rep Opinion
  contributor:
    fullname: N. M. Yussif
– volume-title: Carranza’s Clinical Periodontology
  year: 2006
  ident: 2
  contributor:
    fullname: M. G. Newman
– ident: 26
  doi: 10.18632/oncotarget.14887
– ident: 14
  doi: 10.3390/microorganisms9061218
– ident: 12
  doi: 10.3390/dj11010002
– ident: 25
  doi: 10.4103/0972-124x.142450
– ident: 24
  doi: 10.1136/bcr-2014-208559
– ident: 8
  doi: 10.1051/mmnp/20105101
– ident: 4
  doi: 10.1111/j.1755-148x.2008.00506.x
– ident: 9
  doi: 10.1016/0030-4220(63)90299-8
– ident: 22
  doi: 10.1001/archderm.1957.01550140112021
SSID ssj0000314516
Score 2.3459735
Snippet Harmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
hindawi
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 4586923
SubjectTerms Acids
Ascorbic acid
Clinical trials
Connective tissue
Gingiva
Hyperpigmentation
Melanin
Melanocytes
Oral hygiene
Pain
Pigmentation
Statistical analysis
Teeth
Vitamin C
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYqLu2l6oO2obRyJThGbOI4sbnBtnSLBId2qbhFfkxKpMW7gkX8D34xM06y2q0qcektip2XZxx_nz3-hrE9W4LTtpBpXlQmLUxTpFqUkBrEtiTP5bO4gn92Xk4uitNLebmW6otiwjp54K7hDoSwQjUgJFRQIBtQlZVO-1xBo1ShOmiUyTUyFf_BImagHSLdpSSSLw4KqUqdi40xKEr1I_q9Ig583_4Laf4dMLk2Ap28Yi976MiPuld-zZ5BeMOef6VwH8rY9pY9xHDO4W_Gv1MuInQkfgYzE9rAJ8g5bxbtn-t-v1Hg0yHMnNN8LP8RaFaGNlPx3-3SXOM1Y26C57_wfguY8emg-HrIj_hPLJmjm4Dn4y7gfUaH_VZLvDe69ja7OPk2HU_SPudC6hDZLFNsW4MUyWmFoxjIzOXCAfbSEirXkLqfLrFC4_woBwR3yD6xbuYRhoxKkzkr3rGtMA_wgfGRNAgvrPOZByQ52vqqsQI0IirfeC0Stj9YoV500hp1pCRS1mSturdWwo7JRKs6JIgdT6Cb1L2b1E-5ScL2egM_8azdwfp135lva1prVLqsRlnCvqyKsX1pbcUEmN9RnZzUuDKhEva-c5bVg0SVSySqMmFqw402vmizJLRXUeqbEq_nyOl2_kcbfGQv6Fu7CaRdtrW8uYNPCKmW9nPsPY9snR5L
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Open Access: Hindawi Publishing
  dbid: RHX
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELbYXuAF8ZvAQEYajxFNHDs2b6MwCtJ4GB3qW-QfFxapc6utE_8HfzF3iVPRgQRvTe0kTe8u_j77_B1jh06BN66SeVnVNq9sW-VGKMgtYluS5wpFv4J_8kXNzqrPC7lIIklXfy7h42hH9Fy8qaRWiEX22J7WJJF_Oltsp1JIgV32RU4LhSGj61KPKe43Tt8ZfHqNfoS950R-f3R_g5g3MyV_G3qO77G7CTPyo8HI99ktiA_Y7feU50Ol2h6yn30e5_ga4x-pCBF6ED-BpY1d5DMkm5fr7vtF2mgU-XzML-c0Ecs_RZqOoV1U_Fu3sRd4zpTbGPhXvN4alnw-Sr2-5Uf8FFtW6B8Q-HTIdF_Sx7THEq-NPv2InR1_mE9neSq2kHuENJtcemORG3mjcfgCWfhSeMDwVFD7lmT9jMIOrQ-TEhDVIe3EvkVA_DFRtvBOPGb7cRXhKeMTaRFXOB-KAMhujAt16wQYhFKhDUZk7PVohWY9aGo0PReRsiFrNclaGXtHJtr2ISXs_gv0jiYFViOEE7oFIaGGCtmirh0-Sig1tOgp2mbsMBn4H_c6GK3fpCi-amiRURtVT4qMvdo24_9Liyo2wuqa-pQkw1UInbEng7NsbyTqUiJDlRnTO26080S7LbE77zW-qeJ6iWTu2f_9_OfsDh0Oc0MHbH9zeQ0vEC1t3Ms-Vn4BmdANow
  priority: 102
  providerName: Hindawi Publishing
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3fb9MwELZge4AXxG8CAxlpPEZr7DixeUFb2ShIm9Do0N4ix75skTqndJ34P_iLuUudQhGCtyh2k7h3tr_v7nzH2G5dgDN1rlKRlzbNbZOnRhaQWsS2lJ7LZ70H__ikmJzln87VeTS4XcewymFN7Bdq3zmyke-Rw0ebohxl7-bfUqoaRd7VWELjNtsWWU5u2u2Dw5PPp2srCyVnV33906zA2aRLoYfod6WI-Mu9XOnCCLmxL_Xp-xERXxIv_t7-DX3-GUT52650dJ_di3CS76_k_4DdgvCQ3XlPIUBUxe0R-9GHeA4rHP9A9YlQufgxzGxoA58gD13M24ureAYp8OkQes7JRss_BrLU0AEr_rVd2iv8zZjb4PkXfN4cZnw6ZIF9y_f5KbZ0qDrg-XgVBD-jy3j8Ep-N6v6YnR0dTseTNNZhSB2inWWqnLFIm5zRuLOBypyQDnDmFlC6hjL-mQI7NM6PBCDgQ0aKfTOP0GRU2MzV8gnbCl2AZ4yPlEXIUTufeUDiY2pfNrUEgyjLN97IhL0ZpFDNV-k2qp6mKFWRtKoorYQdkIjWfShJdn-jW1xUcc5VUtZSNyAVlJAjkdRljUPxQkOjda5twnajgP_zrp1B-lWc4NfVL3VM2Ot1M_6_5G-xAbob6iMoQ1cmdcKerpRl_SJZCoXkVSVMb6jRxog2W0J72af_pmLsAnne839_1wt2l0axMhftsK3l4gZeIoBa1q_iLPkJ7a0ZRg
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELbGeIAXxG_CBjLSeAw0sZ04kxAahVGQygO0aG-RY1-2SJ1buk6Mf2N_8e6cpKLTJHiLYseWfXfx99nnO8b2qgxsUUkVpzI3sTS1jAuRQWwQ21J4LpeEE_zxt2w0lV-P1NEW67ONdhN4diO1o3xS0-XszcWvP-_R4N8Fg1eK-Lt4K5XOEKzcYrdTKSTp-rgD-uGfLEJGWmJfGVqVzlPde8Ffa2BjfQph_BEZnxA__t3chEKvO1P-tTod3mf3OljJD1o9eMC2wD9kdz6SKxBlc3vELoOrZ_-n458pTxEqGR_DzPjG8xHy0eWiOT7t7iJ5Puld0Dnt1fIvnnZs6KIV_9mszCl-M-TGO_4D21vAjE_6aLD7_IB_x5I5qhA4Pmyd4Wf02F3DxLZR7R-z6eGnyXAUd_kYYouoZxUrWxikT7bQuMKBSmwqLKAFZ5DbmiL_FRlWqK0bpIDAD5kp1k0cQpRBZhJbiSds2889PGN8oAxCj8q6xAESoKJyeV0JKBBtudoVImKveymUizbsRhnoilIlSavspBWxDySidR0Klh1ezJfHZWd7pRCV0DUIBTlIJJQ6r3AoLtVQay21idheJ-B_9LXbS7_s9bSkc0hdZPkgidirdTHOL527GA_zc6qTUqSuROiIPW2VZd2RyFOFJFZFTG-o0caINkt8cxLCgFNS9hT53vP_6HiH3aWhtHtHu2x7tTyHF4imVtXLYChXVA4bpw
  priority: 102
  providerName: Scholars Portal
Title Physiological Gingival Melanin Hyperpigmentation Treatment with Injectable Vitamin C and Scalpel Technique: A Randomised Controlled Clinical Trial
URI https://dx.doi.org/10.1155/2023/4586923
https://www.ncbi.nlm.nih.gov/pubmed/37252615
https://www.proquest.com/docview/2819896701
https://search.proquest.com/docview/2820971138
https://pubmed.ncbi.nlm.nih.gov/PMC10212675
https://doaj.org/article/33b38fe35e7e414087b5c9d28ef8848a
Volume 2023
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELe28QAviO8FRmWk8Zi1iWPH4W0r2wpSp6l0qG-Rv7JFat2qdOL_4C_mzkmqFSEh8WJFsfPh3F38-9nnO0KOtXCm0BmP0yxXcaaqLC6YcLECbIvhuWwSVvDHV2J0k32d8dkeEd1emOC0b3R94ueLE1_fBd_K1cL0Oz-x_vV4iOmoU0C6_X2ynzP2gKOH_y8L2WeRaQmwIJmnsvN45xzJPutnXIoiZTtjUQjZDyj4Drnwz_pviPNPx8kHI9HFM_K0hZD0tHnV52TP-Rfk8Wd0-8HMbS_Jr-DW2f3V6CXmJAKFomM3V772dATcc72qbxftviNPp527OcV5WfrF4-wMbqqi3-uNWsA1Q6q8pd_gfis3p9Mu8usnekonULMEdXGWDhvH9zketlsu4d6g4q_IzcX5dDiK29wLsQGEs4m5KRRQJVNIGM0cT0zKjANrFS43FUb5KwQ0qIwdpA5AHrBQaJtYgCMDoRKj2Wty4JfeHRI64ApghjY2sQ7ITqFtXmnmCkBWtrIFi8jHTgrlqgmxUQZqwnmJ0ipbaUXkDEW0bYOBscOJ5fq2bNWjZEwzWTnGXe4yII8y19AVm0pXSZlJFZHjVsD_eNZRJ_2yNeofJa45ykLkgyQiH7bV8H1xjUV5t7zHNilG5UqYjMibRlm2D2J5yoGw8ojIHTXa6dFuDVhACPndafzb_7_0HXmCPWymj47IwWZ9794DoNroHljRLO-RR2fnV9eTXpiWgPJylkA5ziSUk9GsF6zsN-IjJb0
link.rule.ids 230,315,733,786,790,869,870,883,884,891,2115,4043,12083,21416,24346,27954,27955,27956,31752,31753,33777,33778,43343,43838,53825,53827,74100,74657
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3fb9MwELZgPIwXxO-FDTDSeIzWxHZs84JGYXSw7gE61LfIsZ0tUud0XSf-D_5i7lKnUITgLYrdJO7d2d93Pt8Rsl8V3uqKizTn0qTc1DzVrPCpAWyL6blc1u3gj0-L0Rn_NBXT6HC7jmGV_ZzYTdSutegjP8ANH6ULOcjezq9SrBqFu6uxhMZtcoczxlHP5VSufSyYml101U-zAmxJyVz1se9CIO1nB1yoQudsY1XqkvcDHr5AVvy9-Rv2_DOE8rc16eg-uRfBJD1cSf8BueXDQ7L9HgOAsIbbI_KjC_Ds5zf6EasTgWrRsZ-Z0AQ6Aha6mDfnl_EEUqCTPvCcooeWHgf00-DxKvqtWZpL-M2QmuDoV3je3M_opM8B-4Ye0i_Q0oLieEeHqxD4GV7Gw5fwbFD2x-Ts6MNkOEpjFYbUAtZZpsJqA6TJagXrmheZzZn1YLeFl7bGfH-6gA61dYPcA9wDPgp9MwfAZFCYzFbsCdkKbfA7hA6EAcBRWZc5D7RHV07WFfMaMJarnWYJed1LoZyvkm2UHUkRokRplVFaCXmHIlr3wRTZ3Y12cV5GiysZq5iqPRNeeg40UskKhuJy5WuluDIJ2Y8C_s-79nrpl9G8r8tfypiQV-tm-H9xt8UE395gnxzzc2VMJeTpSlnWL2IyF0BdRULUhhptjGizJTQXXfJvLMWeA8t79u_vekm2R5PxSXlyfPp5l9zFEa0cR3tka7m48c8BSi2rF529_ASJaBrN
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3fb9MwELZgSMAL4jeBAUYaj1GTOI5tXtDoKB2wCUGH-hY5trNF6pzSdeL_4C_mLnEKRQjeothN4t6d_d358x0he1XhjKpyHme50HGu6zxWrHCxBmyL6bls2u3gHx0X05P8_ZzPA__pItAqhzmxm6htazBGPsINH6kKkaSjOtAiPh1MXi-_xVhBCndaQzmNq-QarJIJlnEQc7GJt2Cadt5VQk0LsCspMjnw4DnHEAAb5VwWKmNbK1SXyB-w8Rl6yN-bv-HQP-mUv61Pk9vkVgCWdL_XhDvkivN3yY0DJANhPbd75EdH9hzmOvoOKxWBmtEjt9C-8XQKHulq2Zyeh9NIns4GEjrFaC099BizwaNW9Guz1ufwmzHV3tIv8LylW9DZkA_2Fd2nn6GlBSVylo57OvwCL8NBTHg2KP59cjJ5OxtP41CRITaAe9YxN0qDA2WUhDXO8dRkzDiw4cIJU2PuP1VAh9rYJHMA_cA3hb6pBZCSFDo1FXtAdnzr3SNCE64BfFTGptaBC6QqK-qKOQV4y9ZWsYi8HKRQLvvEG2XnsHBeorTKIK2IvEERbfpguuzuRrs6LYP1lYxVTNaOcSdcDi6lFBUMxWbS1VLmUkdkLwj4P-_aHaRfBlO_KH8pZkRebJrh_8WdF-1de4l9MszVlTIZkYe9smxexETGwY3lEZFbarQ1ou0W35x1icCxLHsGHt_jf3_Xc3IdTKX8eHj84Qm5iQPqY0i7ZGe9unRPAVWtq2edufwE0kQe-Q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Physiological+Gingival+Melanin+Hyperpigmentation+Treatment+with+Injectable+Vitamin+C+and+Scalpel+Technique%3A+A+Randomised+Controlled+Clinical+Trial&rft.jtitle=International+journal+of+dentistry&rft.au=Chaudhary%2C+Dhanashree+S&rft.au=Parwani%2C+Simran+R&rft.au=Barkhade%2C+Shital&rft.au=Gajbhiye%2C+Minal&rft.date=2023&rft.issn=1687-8728&rft.volume=2023&rft.spage=4586923&rft.epage=4586923&rft_id=info:doi/10.1155%2F2023%2F4586923&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1687-8728&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1687-8728&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1687-8728&client=summon