Embryonic lethality caused by mutations in basement membrane collagen of C. elegans
Basement membranes are specialized forms of extracellular matrix with important functions in development. A major structural component of basement membranes is type IV collagen, a heterotrimer of two alpha 1(IV) and one alpha 2(IV) chains, which forms a complex, polygonal network associated with oth...
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| Published in | Nature (London) Vol. 349; no. 6311; pp. 707 - 709 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing
21.02.1991
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Basement membranes are specialized forms of extracellular matrix with important functions in development. A major structural component of basement membranes is type IV collagen, a heterotrimer of two alpha 1(IV) and one alpha 2(IV) chains, which forms a complex, polygonal network associated with other basement membrane components. Here we report that the alpha 1(IV) collagen chain of Caenorhabditis elegans is encoded by the genetic locus emb-9. Mutations in emb-9 cause temperature-sensitive lethality during late embryogenesis. We have identified single nucleotide alterations that substitute glutamic acid for glycine in the triple-helical Gly-X-Y repeat region of the alpha 1(IV) collagen in three emb-9 mutant strains. These results are direct evidence that defects in basement membranes can disrupt embryonic development and form a basis for the genetic analysis of basement membrane function. |
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| AbstractList | Basement membranes are specialized forms of extracellular matrix with important functions in development. A major structural component of basement membranes is type IV collagen, a heterotrimer of two alpha 1(IV) and one alpha 2(IV) chains, which forms a complex, polygonal network associated with other basement membrane components. Here we report that the alpha 1(IV) collagen chain of Caenorhabditis elegans is encoded by the genetic locus emb-9. Mutations in emb-9 cause temperature-sensitive lethality during late embryogenesis. We have identified single nucleotide alterations that substitute glutamic acid for glycine in the triple-helical Gly-X-Y repeat region of the alpha 1(IV) collagen in three emb-9 mutant strains. These results are direct evidence that defects in basement membranes can disrupt embryonic development and form a basis for the genetic analysis of basement membrane function. Here we report that the alpha 1(IV) collagen chain of Caenorhabditis elegans is encoded by the genetic locus emb-9. Mutations in emb-9 cause temperature-sensitive lethality during late embryogenesis. We have identified single nucleotide alterations that substitute glutamic acid for glycine in the triple-helical Gly-X-Y repeat region of the alpha 1(IV) collagen in three emb-9 mutant strains. These results are direct evidence that defects in basement membranes can disrupt embryonic development and form a basis for the genetic analysis of basement membrane function. The alpha1(IV) collagen chain of Caenorhabditis elegans is found to be encoded by the genetic locus emb-9. Direct evidence is revealed that defects in basement membranes can disrupt embryonic development and form a basis for the genetic analysis of basement membrane function. BASEMENT membranes are specialized forms of extracellular matrix with important functions in development1-3. A major structural component of basement membranes is type IV collagen, a heterotrimer of two al(IV) and one a2(IV) chains, which forms a complex, polygonal network associated with other basement membrane components4,5. Here we report that the al(IV) collagen chain of Caenorhabditis elegans is encoded by the genetic locus emb-9. Mutations in emb-9 cause temperature-sensitive lethality during late embryogenesis. We have identified single nucleotide alterations that substitute glutamic acid for glycine in the triplehelical Gly-X-Y repeat region of the otl(IV) collagen in three emb-9 mutant strains. These results are direct evidence that defects in basement membranes can disrupt embryonic development and form a basis for the genetic analysis of basement membrane function. |
| Author | Guo, Xiaodu Johnson, Jeffrey J Kramer, James M |
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| Cites_doi | 10.1093/nar/15.5.2295 10.1016/0012-1606(83)90376-7 10.1038/316363a0 10.1056/NEJM198408093110606 10.1016/0092-8674(88)90214-0 10.1016/0014-5793(87)81155-9 10.1016/S0232-1513(86)80002-0 10.1126/science.2349482 10.1111/j.1432-1033.1987.tb13450.x 10.1111/j.1432-1033.1989.tb14673.x 10.1016/0012-1606(80)90369-3 10.1016/S0021-9258(18)71530-5 10.1016/0012-1606(80)90445-5 10.1083/jcb.105.6.2559 10.1042/bj2290287 10.1111/j.1432-1033.1985.tb09186.x 10.1016/S0021-9258(17)39662-X 10.1016/S0021-9258(19)81363-7 10.1146/annurev.cb.03.110187.000421 10.1126/science.4071043 10.1002/j.1460-2075.1986.tb04550.x 10.1128/MCB.10.5.2081 10.1016/0378-1119(84)90153-7 10.1073/pnas.87.4.1606 10.1016/0012-1606(81)90383-3 10.1126/science.239.4839.487 |
| ContentType | Journal Article |
| Copyright | 1991 INIST-CNRS Copyright Macmillan Journals Ltd. Feb 21, 1991 Copyright Nature Publishing Group Feb 21, 1991 |
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| Keywords | Caenorhabditis elegans Embryonic development Nucleotide sequence Collagen Mortality Helmintha Nemathelminthia Glycoproteins Mutation Invertebrata Nematoda |
| Language | English |
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| References | WB Wood (BF349707a0_CR8) 1980; 74 DJ Prockop (BF349707a0_CR12) 1984; 311 I Greenwald (BF349707a0_CR7) 1987; 15 B Blumberg (BF349707a0_CR18) 1988; 263 S Henikoff (BF349707a0_CR22) 1984; 28 T Pihlajaniemi (BF349707a0_CR23) 1985; 260 DF Barker (BF349707a0_CR21) 1990; 248 PD Yurchenco (BF349707a0_CR5) 1987; 105 JM Kramer (BF349707a0_CR15) 1990; 10 R Soininen (BF349707a0_CR25) 1987; 225 R Casada (BF349707a0_CR10) 1981; 84 R Timpl (BF349707a0_CR2) 1986; 29 RW Glanville (BF349707a0_CR17) 1985; 152 A Fire (BF349707a0_CR27) 1986; 5 RK Saiki (BF349707a0_CR26) 1988; 239 GR Martin (BF349707a0_CR3) 1987; 3 R Timpl (BF349707a0_CR4) 1989; 180 J Bonadio (BF349707a0_CR19) 1985; 316 JM Kramer (BF349707a0_CR14) 1988; 55 E Isnenghi (BF349707a0_CR11) 1983; 98 SL Hostikka (BF349707a0_CR20) 1990; 87 J Miwa (BF349707a0_CR9) 1980; 76 M Bernfield (BF349707a0_CR1) 1984 RM Myers (BF349707a0_CR16) 1985; 230 BF349707a0_CR24 KSE Cheah (BF349707a0_CR13) 1985; 229 X Guo (BF349707a0_CR6) 1989; 264 |
| References_xml | – volume: 15 start-page: 2295 year: 1987 ident: BF349707a0_CR7 publication-title: Nucleic Acids Res. doi: 10.1093/nar/15.5.2295 contributor: fullname: I Greenwald – volume: 98 start-page: 465 year: 1983 ident: BF349707a0_CR11 publication-title: Devl Biol. doi: 10.1016/0012-1606(83)90376-7 contributor: fullname: E Isnenghi – volume: 316 start-page: 363 year: 1985 ident: BF349707a0_CR19 publication-title: Nature doi: 10.1038/316363a0 contributor: fullname: J Bonadio – start-page: 545 volume-title: The Role of Extracellular Matrix in Development year: 1984 ident: BF349707a0_CR1 contributor: fullname: M Bernfield – volume: 311 start-page: 376 year: 1984 ident: BF349707a0_CR12 publication-title: New Eng. J. Med. doi: 10.1056/NEJM198408093110606 contributor: fullname: DJ Prockop – volume: 55 start-page: 555 year: 1988 ident: BF349707a0_CR14 publication-title: Cell doi: 10.1016/0092-8674(88)90214-0 contributor: fullname: JM Kramer – volume: 225 start-page: 188 year: 1987 ident: BF349707a0_CR25 publication-title: FEBS Lett. doi: 10.1016/0014-5793(87)81155-9 contributor: fullname: R Soininen – volume: 29 start-page: 1 year: 1986 ident: BF349707a0_CR2 publication-title: Int. Rev. exp. Pathol. doi: 10.1016/S0232-1513(86)80002-0 contributor: fullname: R Timpl – volume: 248 start-page: 1224 year: 1990 ident: BF349707a0_CR21 publication-title: Science doi: 10.1126/science.2349482 contributor: fullname: DF Barker – ident: BF349707a0_CR24 doi: 10.1111/j.1432-1033.1987.tb13450.x – volume: 180 start-page: 487 year: 1989 ident: BF349707a0_CR4 publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1989.tb14673.x contributor: fullname: R Timpl – volume: 76 start-page: 160 year: 1980 ident: BF349707a0_CR9 publication-title: Devl Biol. doi: 10.1016/0012-1606(80)90369-3 contributor: fullname: J Miwa – volume: 264 start-page: 17574 year: 1989 ident: BF349707a0_CR6 publication-title: J. biol. Chem. doi: 10.1016/S0021-9258(18)71530-5 contributor: fullname: X Guo – volume: 74 start-page: 446 year: 1980 ident: BF349707a0_CR8 publication-title: Devl Biol. doi: 10.1016/0012-1606(80)90445-5 contributor: fullname: WB Wood – volume: 105 start-page: 2559 year: 1987 ident: BF349707a0_CR5 publication-title: J. Cell Biol. doi: 10.1083/jcb.105.6.2559 contributor: fullname: PD Yurchenco – volume: 229 start-page: 287 year: 1985 ident: BF349707a0_CR13 publication-title: Biochem. J. doi: 10.1042/bj2290287 contributor: fullname: KSE Cheah – volume: 152 start-page: 213 year: 1985 ident: BF349707a0_CR17 publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1985.tb09186.x contributor: fullname: RW Glanville – volume: 260 start-page: 7681 year: 1985 ident: BF349707a0_CR23 publication-title: J. biol. Chem. doi: 10.1016/S0021-9258(17)39662-X contributor: fullname: T Pihlajaniemi – volume: 263 start-page: 18328 year: 1988 ident: BF349707a0_CR18 publication-title: J. biol. Chem. doi: 10.1016/S0021-9258(19)81363-7 contributor: fullname: B Blumberg – volume: 3 start-page: 57 year: 1987 ident: BF349707a0_CR3 publication-title: A. Rev. Cell Biol. doi: 10.1146/annurev.cb.03.110187.000421 contributor: fullname: GR Martin – volume: 230 start-page: 1242 year: 1985 ident: BF349707a0_CR16 publication-title: Science doi: 10.1126/science.4071043 contributor: fullname: RM Myers – volume: 5 start-page: 2673 year: 1986 ident: BF349707a0_CR27 publication-title: EMBO J. doi: 10.1002/j.1460-2075.1986.tb04550.x contributor: fullname: A Fire – volume: 10 start-page: 2081 year: 1990 ident: BF349707a0_CR15 publication-title: Molec. cell. Biol. doi: 10.1128/MCB.10.5.2081 contributor: fullname: JM Kramer – volume: 28 start-page: 351 year: 1984 ident: BF349707a0_CR22 publication-title: Gene doi: 10.1016/0378-1119(84)90153-7 contributor: fullname: S Henikoff – volume: 87 start-page: 1606 year: 1990 ident: BF349707a0_CR20 publication-title: Proc. natn. Acad. Sci. U.S.A. doi: 10.1073/pnas.87.4.1606 contributor: fullname: SL Hostikka – volume: 84 start-page: 193 year: 1981 ident: BF349707a0_CR10 publication-title: Devl Biol. doi: 10.1016/0012-1606(81)90383-3 contributor: fullname: R Casada – volume: 239 start-page: 487 year: 1988 ident: BF349707a0_CR26 publication-title: Science doi: 10.1126/science.239.4839.487 contributor: fullname: RK Saiki |
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| Snippet | Basement membranes are specialized forms of extracellular matrix with important functions in development. A major structural component of basement membranes is... BASEMENT membranes are specialized forms of extracellular matrix with important functions in development1-3. A major structural component of basement membranes... Here we report that the alpha 1(IV) collagen chain of Caenorhabditis elegans is encoded by the genetic locus emb-9. Mutations in emb-9 cause... The alpha1(IV) collagen chain of Caenorhabditis elegans is found to be encoded by the genetic locus emb-9. Direct evidence is revealed that defects in basement... |
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| SubjectTerms | Amino Acid Sequence Animals Base Sequence Basement Membrane - chemistry Basement membranes Biological and medical sciences Caenorhabditis - embryology Caenorhabditis - genetics Caenorhabditis - growth & development Caenorhabditis elegans Cellular biology Chains Collagen Collagen (type IV) Collagen - genetics Collagen - physiology Defects Embryogenesis Embryonic growth stage Extracellular matrix Fundamental and applied biological sciences. Psychology Genes Genetic analysis Genotype & phenotype Glutamic acid Glycine Humans Lethality Medical research Membranes Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis. Repair Mutation Sequence Homology, Nucleic Acid Temperature |
| Title | Embryonic lethality caused by mutations in basement membrane collagen of C. elegans |
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