Association of antipsychotic drugs on type 2 diabetes mellitus risk in patients with schizophrenia: a population-based cohort and in vitro glucose homeostasis-related gene expression study

• Published in: BMC psychiatry Vol. 24; no. 1; pp. 751 - 13
• Main Authors: Fang, Yi-Jen, Lee, Wan-Yi, Lin, Cheng-Li, Cheah, Yu-Cun, Hsieh, Hui-Hsia, Chen, Chi-Hua, Tsai, Fuu-Jen, Tien, Ni, Lim, Yun-Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.10.2024; BioMed Central; BMC
• Subjects: Adult; Antipsychotic Agents - adverse effects; Antipsychotic Agents - therapeutic use; Antipsychotic drugs; Antipsychotic medications; Antipsychotics; Cardiovascular disease; Cell lines; Chronic illnesses; Cohort study; Complications and side effects; Dextrose; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes therapy; Dopamine; Drug therapy; Drugs; Female; Gene expression; Gene Expression - drug effects; Gene Expression - genetics; Genes; Gluconeogenesis; Glucose; Glucose - metabolism; Glucose homeostasis; Health insurance; Hepatocytes; Homeostasis; Homeostasis - drug effects; Humans; Hyperglycemia; Hyperlipidemia; Hypertension; Incidence; Insulin resistance; Liver; Male; Medical research; Medicine, Experimental; Mental disorders; Middle Aged; Mortality; Patients; Population; Population studies; Psychotropic drugs; Retrospective Studies; Risk Factors; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - epidemiology; Schizophrenia - genetics; Taiwan - epidemiology; Type 2 diabetes; Type 2 diabetes mellitus; Taiwan; Antipsychotic medications; Schizophrenia; Type 2 diabetes mellitus; Glucose homeostasis; Cohort study

Type 2 diabetes mellitus (T2DM) and its related complications are associated with schizophrenia. However, the relationship between antipsychotic medications (APs) and T2DM risk remains unclear. In this population-based, retrospective cohort study across the country, we investigated schizophrenia and...