Integrative multi-omic analysis reveals potential biomarkers in the cervicovaginal fluid of patients with placenta accrete spectrum

• Published in: BMC pregnancy and childbirth Vol. 24; no. 1; pp. 856 - 12
• Main Authors: Jiang, Hai, Qu, Jiangxue, Huang, Nana, Li, Zeli, Shi, Xiaoming, Chen, Lian, Zhao, Yangyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central 24.12.2024; BMC
• Subjects: Adult; Biomarker; Biomarkers; Biomarkers - analysis; Biomarkers - metabolism; Body Fluids - chemistry; Body Fluids - metabolism; Case-Control Studies; Cervicovaginal fluid; Cervix; Cervix Uteri - metabolism; Female; Gestational age; Humans; Hysterectomy; Medical diagnosis; Metabolites; Metabolomic; Metabolomics - methods; Multiomics; Placenta; Placenta Accreta - metabolism; Placenta accrete spectrum; Postpartum period; Pregnancy; Pregnancy complications; Proteins; Proteomic; Proteomics; Proteomics - methods; Signal transduction; Software; Ultrasonic imaging; Uterus; Vagina; Vagina - metabolism; Womens health; Metabolomic; Biomarker; Cervicovaginal fluid; Placenta accrete spectrum; Proteomic

This study aimed to detect the proteins and metabolites in the cervicovaginal fluid to observe their relationship with the occurrence of placenta accreta spectrum and the potential biomarkers with predictive value. Cervicovaginal fluid samples were collected before delivery from 6 participants of PA...