Design and Development of Autotaxin Inhibitors

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 11; p. 1203
• Main Authors: Jia, Yi, Li, Yan, Xu, Xu-Dong, Tian, Yu, Shang, Hai
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.11.2021; MDPI
• Subjects: Amino acids; autotaxin; Binding sites; Cancer; Cell growth; development; Disease; inhibitor; Lipids; lysophosphatidic acid; Melanoma; Metabolism; Motility; Nervous system; Physiology; Pruritus; Review; structure design; Zinc

Autotaxin (ATX) is the only enzyme of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP2) family with lysophospholipase D (lysoPLD) activity, which is mainly responsible for the hydrolysis of extracellular lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). LPA can induce vario...