Genetic variation in the base excision repair pathway and bladder cancer risk

• Published in: Human genetics Vol. 121; no. 2; pp. 233 - 242
• Main Authors: Figueroa, Jonine D., Malats, Núria, Real, Francisco X., Silverman, Debra, Kogevinas, Manolis, Chanock, Stephen, Welch, Robert, Dosemeci, Mustafa, Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Castaño-Vinyals, Gemma, Rothman, Nathaniel, García-Closas, Montserrat
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.04.2007; Berlin Springer Nature B.V; New York, NY
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Bladder cancer; Cancer; Classical genetics, quantitative genetics, hybrids; DNA Damage; DNA Repair; Female; Fundamental and applied biological sciences. Psychology; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetic research; Genetic Variation; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Health aspects; Human; Humans; Male; Medical sciences; Middle Aged; Monosaccharides; Nephrology. Urinary tract diseases; Oncology, Experimental; Polymorphism, Genetic; Risk; Risk factors; Single nucleotide polymorphisms; Sugars; Tumors of the urinary system; Urinary Bladder Neoplasms - genetics; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urinary system disease; Genetic variability; Excision; Genetic variant; Genetics; Risk; Bladder disease; Malignant tumor; Urinary tract disease; Repair; Bladder cancer

Genetic polymorphisms in DNA repair genes may impact individual variation in DNA repair capacity and alter cancer risk. In order to examine the association of common genetic variation in the base-excision repair (BER) pathway with bladder cancer risk, we analyzed 43 single nucleotide polymorphisms (...