Chelerythrine Chloride Alleviated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Glycolytic Pathway Through Targeting Glyceraldehyde-3-Phosphate Dehydrogenase

• Published in: Molecules (Basel, Switzerland) Vol. 30; no. 12; p. 2572
• Main Authors: He, Yuting, Fan, Tianyun, Zhuge, Ruishen, Li, Huiying, Li, Guanjun, Zhou, Lirun, Xu, Liting, Hao, Xiaojiang, Gu, Wei, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.06.2025; MDPI
• Subjects: acute lung injury; Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Animals; Anti-Inflammatory Agents - pharmacology; Benzophenanthridines - pharmacology; chelerythrine chloride; Chelidonium majus L; Cytokines; Dehydrogenases; Disease Models, Animal; Edema; Enzymes; Glucose metabolism; glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism; glycolysis; Glycolysis - drug effects; Health aspects; Inflammation; Inflammatory diseases; Interleukins; Investigations; Labeling; Lipopolysaccharides - adverse effects; Lung diseases; Male; Metabolism; Metabolites; Mice; Monosaccharides; Nitric oxide; Nitric Oxide - metabolism; Phosphates; Proteins; RAW 264.7 Cells; Sugars; Toxicity; Tumor necrosis factor; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; China; chelerythrine chloride; Chelidonium majus L; glyceraldehyde-3-phosphate dehydrogenase; acute lung injury; glycolysis

Acute lung injury (ALI) is a fatal respiratory disease caused by excessive inflammation. Chelerythrine chloride (CH), an isoquinoline alkaloid, exhibits diverse biological activities. The research focused on assessing CH’s therapeutic effects against LPS-mediated ALI in mice and its underlying mecha...