Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 40; no. 2; pp. 463 - 471
• Main Authors: Savitz, Jonathan, Drevets, Wayne C, Smith, Chelsey M, Victor, Teresa A, Wurfel, Brent E, Bellgowan, Patrick SF, Bodurka, Jerzy, Teague, T Kent, Dantzer, Robert
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.01.2015
• Subjects: Acids; Adult; Amygdala - pathology; Anhedonia; Atrophy; Brain research; Brain-Derived Neurotrophic Factor - blood; C-Reactive Protein - metabolism; Comorbidity; Cytokines; Depressive Disorder, Major - blood; Depressive Disorder, Major - pathology; Enzymes; Female; Gray Matter - pathology; Hippocampus - pathology; Humans; Inflammation; Kynurenic Acid - blood; Kynurenine - analogs & derivatives; Kynurenine - blood; Male; Mental depression; Metabolites; Neurogenesis; Neurotoxicity; Organ Size; Original; Psychiatric Status Rating Scales; Quinolinic Acid - blood; Receptors, Interleukin-1 - blood; Signal Transduction; Tryptophan - blood; Tumor necrosis factor-TNF; United States > US

Inflammation-related changes in the concentrations of kynurenine pathway metabolites occur in depression secondary to medical conditions but are not firmly established in primary mood disorders. Reductions in hippocampal and amygdalar volume that putatively reflect dendritic atrophy are widely repor...