Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein

Optimized negative-staining and cryo–positive staining EM reveals that human cholesteryl ester transfer protein penetrates into HDL and LDL from each distal end and potentially forms a continuous tunnel by connecting its internal series of isolated hydrophobic cavities together for cholesteryl ester...

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Published inNature chemical biology Vol. 8; no. 4; pp. 342 - 349
Main Authors Zhang, Lei, Yan, Feng, Zhang, Shengli, Lei, Dongsheng, Charles, M Arthur, Cavigiolio, Giorgio, Oda, Michael, Krauss, Ronald M, Weisgraber, Karl H, Rye, Kerry-Anne, Pownall, Henry J, Qiu, Xiayang, Ren, Gang
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 19.02.2012
Nature Publishing Group
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Abstract Optimized negative-staining and cryo–positive staining EM reveals that human cholesteryl ester transfer protein penetrates into HDL and LDL from each distal end and potentially forms a continuous tunnel by connecting its internal series of isolated hydrophobic cavities together for cholesteryl ester transfer. Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism. Delineating this mechanism would be an important step toward the rational design of new CETP inhibitors for treating cardiovascular diseases. Using EM, single-particle image processing and molecular dynamics simulation, we discovered that CETP bridges a ternary complex with its N-terminal β-barrel domain penetrating into high-density lipoproteins and its C-terminal domain interacting with low-density lipoprotein or very-low-density lipoprotein. In our mechanistic model, the CETP lipoprotein-interacting regions, which are highly mobile, form pores that connect to a hydrophobic central cavity, thereby forming a tunnel for transfer of neutral lipids from donor to acceptor lipoproteins. These new insights into CETP transfer provide a molecular basis for analyzing mechanisms for CETP inhibition.
AbstractList Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism. Delineating this mechanism would be an important step toward the rational design of new CETP inhibitors for treating cardiovascular diseases. Using EM, single-particle image processing and molecular dynamics simulation, we discovered that CETP bridges a ternary complex with its N-terminal β-barrel domain penetrating into high-density lipoproteins and its C-terminal domain interacting with low-density lipoprotein or very-low-density lipoprotein. In our mechanistic model, the CETP lipoprotein-interacting regions, which are highly mobile, form pores that connect to a hydrophobic central cavity, thereby forming a tunnel for transfer of neutral lipids from donor to acceptor lipoproteins. These new insights into CETP transfer provide a molecular basis for analyzing mechanisms for CETP inhibition.
Optimized negative-staining and cryo–positive staining EM reveals that human cholesteryl ester transfer protein penetrates into HDL and LDL from each distal end and potentially forms a continuous tunnel by connecting its internal series of isolated hydrophobic cavities together for cholesteryl ester transfer. Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to atherogenic low-density lipoproteins by an unknown mechanism. Delineating this mechanism would be an important step toward the rational design of new CETP inhibitors for treating cardiovascular diseases. Using EM, single-particle image processing and molecular dynamics simulation, we discovered that CETP bridges a ternary complex with its N-terminal β-barrel domain penetrating into high-density lipoproteins and its C-terminal domain interacting with low-density lipoprotein or very-low-density lipoprotein. In our mechanistic model, the CETP lipoprotein-interacting regions, which are highly mobile, form pores that connect to a hydrophobic central cavity, thereby forming a tunnel for transfer of neutral lipids from donor to acceptor lipoproteins. These new insights into CETP transfer provide a molecular basis for analyzing mechanisms for CETP inhibition.
Author Krauss, Ronald M
Charles, M Arthur
Lei, Dongsheng
Pownall, Henry J
Ren, Gang
Zhang, Lei
Yan, Feng
Oda, Michael
Rye, Kerry-Anne
Cavigiolio, Giorgio
Weisgraber, Karl H
Zhang, Shengli
Qiu, Xiayang
AuthorAffiliation 10 Pfizer Inc., Groton, Connecticut, USA
9 Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
3 Department of Applied Physics, Xi’an Jiaotong University, Xi’an, China
4 Children’s Hospital Oakland Research Institute, Oakland, California, USA
5 Gladstone Institute of Neurological Disease, University of California–San Francisco, San Francisco, California, USA
6 Lipid Research Group, The Heart Research Institute, Sydney, New South Wales, Australia
2 School of Medicine, University of California–San Francisco, San Francisco, California, USA
1 Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California, USA
7 Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia
8 Department of Medicine, University of Melbourne, Victoria, Australia
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  organization: Molecular Foundry, Lawrence Berkeley National Laboratory, School of Medicine, University of California–San Francisco, Department of Applied Physics, Xi'an Jiaotong University
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Cites_doi 10.1172/JCI116683
10.1016/0021-9150(76)90126-X
10.1111/j.1755-5922.2010.00201.x
10.1345/aph.1P446
10.1194/jlr.D002493
10.1016/S0006-3495(01)76033-X
10.1016/S0022-2836(03)00155-4
10.1194/jlr.D010959
10.1006/jsbi.1996.0030
10.1002/jcc.20289
10.1021/bi802287q
10.1073/pnas.0803626105
10.1073/pnas.98.4.1398
10.1016/0002-9343(77)90874-9
10.1073/pnas.0708667105
10.1097/MOL.0b013e3283475e00
10.1016/S0968-4328(97)00068-1
10.1161/01.ATV.0000054658.91146.64
10.1002/1097-0134(20000815)40:3<512::AID-PROT180>3.0.CO;2-M
10.1038/386088a0
10.1002/pro.101
10.1016/j.ibmb.2006.01.001
10.1038/nsmb1197
10.1002/jcc.20084
10.1006/jmbi.2000.3949
10.1016/j.jsb.2006.05.004
10.1073/pnas.0908004107
10.1038/nsmb.1811
10.1038/342448a0
10.1074/jbc.M303365200
10.1074/jbc.270.2.612
10.1056/NEJM199011013231803
10.1006/jsbi.1999.4174
10.1194/jlr.M300063-JLR200
10.1251/bpo70
10.1038/nature07159
10.1016/S0022-2275(20)38039-1
10.1016/S0022-2275(20)39830-8
10.1016/S0022-2275(20)36957-1
10.1007/978-1-349-09857-6_5
10.1016/S0021-9258(18)60692-1
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PublicationDate 20120219
PublicationDateYYYYMMDD 2012-02-19
PublicationDate_xml – month: 2
  year: 2012
  text: 20120219
  day: 19
PublicationDecade 2010
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PublicationTitle Nature chemical biology
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PublicationYear 2012
Publisher Nature Publishing Group US
Nature Publishing Group
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– name: Nature Publishing Group
References Ren, Reddy, Cheng, Melnyk, Mitra (CR19) 2001; 98
Swenson, Brocia, Tall (CR25) 1988; 263
Weers, Ryan (CR32) 2006; 36
Morton, Greene (CR24) 2003; 44
Zhang (CR14) 2011; 52
Phillips (CR29) 2005; 26
Camejo, Waich, Quintero, Berrizbeitia, Lalaguna (CR2) 1976; 24
Niesor (CR7) 2011; 22
Chen (CR15) 2009; 18
Ren (CR21) 2010; 107
Silva (CR16) 2008; 105
Inazu (CR6) 1990; 323
Wang, Kussie, Deng, Tall (CR36) 1995; 270
Galkin, Orlova, Cherepanova, Lebart, Egelman (CR40) 2008; 105
Qiu (CR10) 2007; 14
Mehta, Gantz, Gursky (CR34) 2003; 328
Böttcher, Wynne, Crowther (CR41) 1997; 386
Flemming, Thierbach, Stelter, Böttcher, Hurt (CR28) 2010; 17
Barter (CR1) 2003; 23
Pettersen (CR26) 2004; 25
Saito (CR33) 2003; 278
Frank (CR38) 1996; 116
Zhang (CR17) 2010; 51
Ren, Cheng, Reddy, Melnyk, Mitra (CR20) 2000; 301
Han (CR35) 2009; 48
CR23
Doruker, Atilgan, Bahar (CR31) 2000; 40
Gordon, Castelli, Hjortland, Kannel, Dawber (CR3) 1977; 62
Ihm, Quinn, Busch, Chataing, Harmony (CR12) 1982; 23
Hayek (CR4) 1993; 92
Miyares (CR8) 2011; 45
Tall (CR13) 1993; 34
Liu, Bartesaghi, Borgnia, Sapiro, Subramaniam (CR27) 2008; 455
Barter, Jones (CR11) 1980; 21
Ohi, Li, Cheng, Walz (CR18) 2004; 6
Grigorieff (CR37) 2007; 157
Atilgan (CR30) 2001; 80
Ludtke, Baldwin, Chiu (CR39) 1999; 128
Adrian, Dubochet, Fuller, Harris (CR22) 1998; 29
Kappelle, van Tol, Wolffenbuttel, Dullaart (CR9) 2010; 29
Brown (CR5) 1989; 342
8409761 - J Lipid Res. 1993 Aug;34(8):1255-74
18668044 - Nature. 2008 Sep 4;455(7209):109-13
15103397 - Biol Proced Online. 2004;6:23-34
21205945 - Ann Pharmacother. 2011 Jan;45(1):84-94
10926515 - J Mol Biol. 2000 Aug 11;301(2):369-87
20978167 - J Lipid Res. 2011 Jan;52(1):175-84
2215607 - N Engl J Med. 1990 Nov 1;323(18):1234-8
10861943 - Proteins. 2000 Aug 15;40(3):512-24
17237796 - Nat Struct Mol Biol. 2007 Feb;14(2):106-13
8376576 - J Clin Invest. 1993 Sep;92(3):1143-52
16551537 - Insect Biochem Mol Biol. 2006 Apr;36(4):231-40
18234857 - Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1494-8
2586614 - Nature. 1989 Nov 23;342(6248):448-51
12730298 - J Lipid Res. 2003 Jul;44(7):1364-72
7822286 - J Biol Chem. 1995 Jan 13;270(2):612-8
20645987 - Cardiovasc Ther. 2011 Dec;29(6):e89-99
16222654 - J Comput Chem. 2005 Dec;26(16):1781-802
19965615 - J Lipid Res. 2010 May;51(5):1228-36
8742743 - J Struct Biol. 1996 Jan-Feb;116(1):190-9
15264254 - J Comput Chem. 2004 Oct;25(13):1605-12
19384992 - Protein Sci. 2009 May;18(5):921-35
2833496 - J Biol Chem. 1988 Apr 15;263(11):5150-7
18719128 - Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12176-81
20512149 - Nat Struct Mol Biol. 2010 Jun;17(6):775-8
20080547 - Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1059-64
19191587 - Biochemistry. 2009 Feb 24;48(7):1481-7
193398 - Am J Med. 1977 May;62(5):707-14
10600563 - J Struct Biol. 1999 Dec 1;128(1):82-97
9684350 - Micron. 1998 Apr-Jun;29(2-3):145-60
21587074 - Curr Opin Lipidol. 2011 Aug;22(4):288-95
9052786 - Nature. 1997 Mar 6;386(6620):88-91
12684007 - J Mol Biol. 2003 Apr 18;328(1):183-92
7373163 - J Lipid Res. 1980 Feb;21(2):238-49
12709430 - J Biol Chem. 2003 Jun 27;278(26):23227-32
11171962 - Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1398-403
12588754 - Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):160-7
7161562 - J Lipid Res. 1982 Dec;23(9):1328-41
16828314 - J Struct Biol. 2007 Jan;157(1):117-25
184797 - Atherosclerosis. 1976 Sep;24(3):341-54
11159421 - Biophys J. 2001 Jan;80(1):505-15
B Böttcher (BFnchembio796_CR41) 1997; 386
L Zhang (BFnchembio796_CR17) 2010; 51
AR Atilgan (BFnchembio796_CR30) 2001; 80
M Adrian (BFnchembio796_CR22) 1998; 29
B Chen (BFnchembio796_CR15) 2009; 18
N Grigorieff (BFnchembio796_CR37) 2007; 157
P Doruker (BFnchembio796_CR31) 2000; 40
G Ren (BFnchembio796_CR21) 2010; 107
RE Morton (BFnchembio796_CR24) 2003; 44
R Mehta (BFnchembio796_CR34) 2003; 328
A Inazu (BFnchembio796_CR6) 1990; 323
H Saito (BFnchembio796_CR33) 2003; 278
J Frank (BFnchembio796_CR38) 1996; 116
X Qiu (BFnchembio796_CR10) 2007; 14
PJ Barter (BFnchembio796_CR1) 2003; 23
SJ Ludtke (BFnchembio796_CR39) 1999; 128
M Han (BFnchembio796_CR35) 2009; 48
EJ Niesor (BFnchembio796_CR7) 2011; 22
EF Pettersen (BFnchembio796_CR26) 2004; 25
T Hayek (BFnchembio796_CR4) 1993; 92
ML Brown (BFnchembio796_CR5) 1989; 342
G Ren (BFnchembio796_CR20) 2000; 301
G Camejo (BFnchembio796_CR2) 1976; 24
J Ihm (BFnchembio796_CR12) 1982; 23
L Zhang (BFnchembio796_CR14) 2011; 52
JC Phillips (BFnchembio796_CR29) 2005; 26
VE Galkin (BFnchembio796_CR40) 2008; 105
J Liu (BFnchembio796_CR27) 2008; 455
S Wang (BFnchembio796_CR36) 1995; 270
AR Tall (BFnchembio796_CR13) 1993; 34
T Gordon (BFnchembio796_CR3) 1977; 62
G Ren (BFnchembio796_CR19) 2001; 98
BFnchembio796_CR23
D Flemming (BFnchembio796_CR28) 2010; 17
M Ohi (BFnchembio796_CR18) 2004; 6
TL Swenson (BFnchembio796_CR25) 1988; 263
PJ Barter (BFnchembio796_CR11) 1980; 21
PM Weers (BFnchembio796_CR32) 2006; 36
PJ Kappelle (BFnchembio796_CR9) 2010; 29
MA Miyares (BFnchembio796_CR8) 2011; 45
RA Silva (BFnchembio796_CR16) 2008; 105
References_xml – volume: 92
  start-page: 1143
  year: 1993
  end-page: 1152
  ident: CR4
  article-title: Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI116683
  contributor:
    fullname: Hayek
– volume: 23
  start-page: 1328
  year: 1982
  end-page: 1341
  ident: CR12
  article-title: Kinetics of plasma protein-catalyzed exchange of phosphatidylcholine and cholesteryl ester between plasma lipoproteins
  publication-title: J. Lipid Res.
  contributor:
    fullname: Harmony
– volume: 24
  start-page: 341
  year: 1976
  end-page: 354
  ident: CR2
  article-title: The affinity of low density lipoproteins for an arterial macromolecular complex. A study in ischemic heart disease and controls
  publication-title: Atherosclerosis
  doi: 10.1016/0021-9150(76)90126-X
  contributor:
    fullname: Lalaguna
– volume: 29
  start-page: e89
  year: 2010
  end-page: e99
  ident: CR9
  article-title: Cholesteryl ester transfer protein inhibition in cardiovascular risk management: ongoing trials will end the confusion
  publication-title: Cardiovasc. Ther.
  doi: 10.1111/j.1755-5922.2010.00201.x
  contributor:
    fullname: Dullaart
– volume: 45
  start-page: 84
  year: 2011
  end-page: 94
  ident: CR8
  article-title: Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitors
  publication-title: Ann. Pharmacother.
  doi: 10.1345/aph.1P446
  contributor:
    fullname: Miyares
– volume: 34
  start-page: 1255
  year: 1993
  end-page: 1274
  ident: CR13
  article-title: Plasma cholesteryl ester transfer protein
  publication-title: J. Lipid Res.
  contributor:
    fullname: Tall
– volume: 51
  start-page: 1228
  year: 2010
  end-page: 1236
  ident: CR17
  article-title: An optimized negative-staining protocol of electron microscopy for apoE4·POPC lipoprotein
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.D002493
  contributor:
    fullname: Zhang
– volume: 80
  start-page: 505
  year: 2001
  end-page: 515
  ident: CR30
  article-title: Anisotropy of fluctuation dynamics of proteins with an elastic network model
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(01)76033-X
  contributor:
    fullname: Atilgan
– volume: 328
  start-page: 183
  year: 2003
  end-page: 192
  ident: CR34
  article-title: Human plasma high-density lipoproteins are stabilized by kinetic factors
  publication-title: J. Mol. Biol.
  doi: 10.1016/S0022-2836(03)00155-4
  contributor:
    fullname: Gursky
– volume: 52
  start-page: 175
  year: 2011
  end-page: 184
  ident: CR14
  article-title: Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.D010959
  contributor:
    fullname: Zhang
– volume: 116
  start-page: 190
  year: 1996
  end-page: 199
  ident: CR38
  article-title: SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields
  publication-title: J. Struct. Biol.
  doi: 10.1006/jsbi.1996.0030
  contributor:
    fullname: Frank
– volume: 26
  start-page: 1781
  year: 2005
  end-page: 1802
  ident: CR29
  article-title: Scalable molecular dynamics with NAMD
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20289
  contributor:
    fullname: Phillips
– volume: 21
  start-page: 238
  year: 1980
  end-page: 249
  ident: CR11
  article-title: Kinetic studies of the transfer of esterified cholesterol between human plasma low and high density lipoproteins
  publication-title: J. Lipid Res.
  contributor:
    fullname: Jones
– volume: 48
  start-page: 1481
  year: 2009
  end-page: 1487
  ident: CR35
  article-title: Disruption of human plasma high-density lipoproteins by streptococcal serum opacity factor requires labile apolipoprotein A-I
  publication-title: Biochemistry
  doi: 10.1021/bi802287q
  contributor:
    fullname: Han
– volume: 105
  start-page: 12176
  year: 2008
  end-page: 12181
  ident: CR16
  article-title: Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0803626105
  contributor:
    fullname: Silva
– volume: 98
  start-page: 1398
  year: 2001
  end-page: 1403
  ident: CR19
  article-title: Visualization of a water-selective pore by electron crystallography in vitreous ice
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.98.4.1398
  contributor:
    fullname: Mitra
– volume: 62
  start-page: 707
  year: 1977
  end-page: 714
  ident: CR3
  article-title: High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
  publication-title: Am. J. Med.
  doi: 10.1016/0002-9343(77)90874-9
  contributor:
    fullname: Dawber
– volume: 105
  start-page: 1494
  year: 2008
  end-page: 1498
  ident: CR40
  article-title: High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0708667105
  contributor:
    fullname: Egelman
– volume: 22
  start-page: 288
  year: 2011
  end-page: 295
  ident: CR7
  article-title: Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism
  publication-title: Curr. Opin. Lipidol.
  doi: 10.1097/MOL.0b013e3283475e00
  contributor:
    fullname: Niesor
– ident: CR23
– volume: 29
  start-page: 145
  year: 1998
  end-page: 160
  ident: CR22
  article-title: Cryo-negative staining
  publication-title: Micron
  doi: 10.1016/S0968-4328(97)00068-1
  contributor:
    fullname: Harris
– volume: 23
  start-page: 160
  year: 2003
  end-page: 167
  ident: CR1
  article-title: Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000054658.91146.64
  contributor:
    fullname: Barter
– volume: 40
  start-page: 512
  year: 2000
  end-page: 524
  ident: CR31
  article-title: Dynamics of proteins predicted by molecular dynamics simulations and analytical approaches: application to α-amylase inhibitor
  publication-title: Proteins
  doi: 10.1002/1097-0134(20000815)40:3<512::AID-PROT180>3.0.CO;2-M
  contributor:
    fullname: Bahar
– volume: 386
  start-page: 88
  year: 1997
  end-page: 91
  ident: CR41
  article-title: Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy
  publication-title: Nature
  doi: 10.1038/386088a0
  contributor:
    fullname: Crowther
– volume: 18
  start-page: 921
  year: 2009
  end-page: 935
  ident: CR15
  article-title: Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes
  publication-title: Protein Sci.
  doi: 10.1002/pro.101
  contributor:
    fullname: Chen
– volume: 36
  start-page: 231
  year: 2006
  end-page: 240
  ident: CR32
  article-title: Apolipophorin III: role model apolipoprotein
  publication-title: Insect Biochem. Mol. Biol.
  doi: 10.1016/j.ibmb.2006.01.001
  contributor:
    fullname: Ryan
– volume: 14
  start-page: 106
  year: 2007
  end-page: 113
  ident: CR10
  article-title: Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb1197
  contributor:
    fullname: Qiu
– volume: 263
  start-page: 5150
  year: 1988
  end-page: 5157
  ident: CR25
  article-title: Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Tall
– volume: 25
  start-page: 1605
  year: 2004
  end-page: 1612
  ident: CR26
  article-title: UCSF Chimera—a visualization system for exploratory research and analysis
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20084
  contributor:
    fullname: Pettersen
– volume: 301
  start-page: 369
  year: 2000
  end-page: 387
  ident: CR20
  article-title: Three-dimensional fold of the human AQP1 water channel determined at 4 Å resolution by electron crystallography of two-dimensional crystals embedded in ice
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.2000.3949
  contributor:
    fullname: Mitra
– volume: 157
  start-page: 117
  year: 2007
  end-page: 125
  ident: CR37
  article-title: FREALIGN: high-resolution refinement of single particle structures
  publication-title: J. Struct. Biol.
  doi: 10.1016/j.jsb.2006.05.004
  contributor:
    fullname: Grigorieff
– volume: 107
  start-page: 1059
  year: 2010
  end-page: 1064
  ident: CR21
  article-title: Model of human low-density lipoprotein and bound receptor based on CryoEM
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0908004107
  contributor:
    fullname: Ren
– volume: 17
  start-page: 775
  year: 2010
  end-page: 778
  ident: CR28
  article-title: Precise mapping of subunits in multiprotein complexes by a versatile electron microscopy label
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1811
  contributor:
    fullname: Hurt
– volume: 342
  start-page: 448
  year: 1989
  end-page: 451
  ident: CR5
  article-title: Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins
  publication-title: Nature
  doi: 10.1038/342448a0
  contributor:
    fullname: Brown
– volume: 278
  start-page: 23227
  year: 2003
  end-page: 23232
  ident: CR33
  article-title: Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M303365200
  contributor:
    fullname: Saito
– volume: 270
  start-page: 612
  year: 1995
  end-page: 618
  ident: CR36
  article-title: Defective binding of neutral lipids by a carboxyl-terminal deletion mutant of cholesteryl ester transfer protein. Evidence for a carboxyl-terminal cholesteryl ester binding site essential for neutral lipid transfer activity
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.2.612
  contributor:
    fullname: Tall
– volume: 323
  start-page: 1234
  year: 1990
  end-page: 1238
  ident: CR6
  article-title: Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199011013231803
  contributor:
    fullname: Inazu
– volume: 128
  start-page: 82
  year: 1999
  end-page: 97
  ident: CR39
  article-title: EMAN: semiautomated software for high-resolution single-particle reconstructions
  publication-title: J. Struct. Biol.
  doi: 10.1006/jsbi.1999.4174
  contributor:
    fullname: Chiu
– volume: 44
  start-page: 1364
  year: 2003
  end-page: 1372
  ident: CR24
  article-title: The surface cholesteryl ester content of donor and acceptor particles regulates CETP: a liposome-based approach to assess the substrate properties of lipoproteins
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M300063-JLR200
  contributor:
    fullname: Greene
– volume: 6
  start-page: 23
  year: 2004
  end-page: 34
  ident: CR18
  article-title: Negative staining and image classification - powerful tools in modern electron microscopy
  publication-title: Biol. Proced. Online
  doi: 10.1251/bpo70
  contributor:
    fullname: Walz
– volume: 455
  start-page: 109
  year: 2008
  end-page: 113
  ident: CR27
  article-title: Molecular architecture of native HIV-1 gp120 trimers
  publication-title: Nature
  doi: 10.1038/nature07159
  contributor:
    fullname: Subramaniam
– volume: 128
  start-page: 82
  year: 1999
  ident: BFnchembio796_CR39
  publication-title: J. Struct. Biol.
  doi: 10.1006/jsbi.1999.4174
  contributor:
    fullname: SJ Ludtke
– volume: 278
  start-page: 23227
  year: 2003
  ident: BFnchembio796_CR33
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M303365200
  contributor:
    fullname: H Saito
– volume: 386
  start-page: 88
  year: 1997
  ident: BFnchembio796_CR41
  publication-title: Nature
  doi: 10.1038/386088a0
  contributor:
    fullname: B Böttcher
– volume: 24
  start-page: 341
  year: 1976
  ident: BFnchembio796_CR2
  publication-title: Atherosclerosis
  doi: 10.1016/0021-9150(76)90126-X
  contributor:
    fullname: G Camejo
– volume: 342
  start-page: 448
  year: 1989
  ident: BFnchembio796_CR5
  publication-title: Nature
  doi: 10.1038/342448a0
  contributor:
    fullname: ML Brown
– volume: 23
  start-page: 1328
  year: 1982
  ident: BFnchembio796_CR12
  publication-title: J. Lipid Res.
  doi: 10.1016/S0022-2275(20)38039-1
  contributor:
    fullname: J Ihm
– volume: 80
  start-page: 505
  year: 2001
  ident: BFnchembio796_CR30
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(01)76033-X
  contributor:
    fullname: AR Atilgan
– volume: 52
  start-page: 175
  year: 2011
  ident: BFnchembio796_CR14
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.D010959
  contributor:
    fullname: L Zhang
– volume: 23
  start-page: 160
  year: 2003
  ident: BFnchembio796_CR1
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/01.ATV.0000054658.91146.64
  contributor:
    fullname: PJ Barter
– volume: 40
  start-page: 512
  year: 2000
  ident: BFnchembio796_CR31
  publication-title: Proteins
  doi: 10.1002/1097-0134(20000815)40:3<512::AID-PROT180>3.0.CO;2-M
  contributor:
    fullname: P Doruker
– volume: 107
  start-page: 1059
  year: 2010
  ident: BFnchembio796_CR21
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0908004107
  contributor:
    fullname: G Ren
– volume: 105
  start-page: 12176
  year: 2008
  ident: BFnchembio796_CR16
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0803626105
  contributor:
    fullname: RA Silva
– volume: 157
  start-page: 117
  year: 2007
  ident: BFnchembio796_CR37
  publication-title: J. Struct. Biol.
  doi: 10.1016/j.jsb.2006.05.004
  contributor:
    fullname: N Grigorieff
– volume: 22
  start-page: 288
  year: 2011
  ident: BFnchembio796_CR7
  publication-title: Curr. Opin. Lipidol.
  doi: 10.1097/MOL.0b013e3283475e00
  contributor:
    fullname: EJ Niesor
– volume: 92
  start-page: 1143
  year: 1993
  ident: BFnchembio796_CR4
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI116683
  contributor:
    fullname: T Hayek
– volume: 29
  start-page: 145
  year: 1998
  ident: BFnchembio796_CR22
  publication-title: Micron
  doi: 10.1016/S0968-4328(97)00068-1
  contributor:
    fullname: M Adrian
– volume: 44
  start-page: 1364
  year: 2003
  ident: BFnchembio796_CR24
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M300063-JLR200
  contributor:
    fullname: RE Morton
– volume: 270
  start-page: 612
  year: 1995
  ident: BFnchembio796_CR36
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.2.612
  contributor:
    fullname: S Wang
– volume: 29
  start-page: e89
  year: 2010
  ident: BFnchembio796_CR9
  publication-title: Cardiovasc. Ther.
  doi: 10.1111/j.1755-5922.2010.00201.x
  contributor:
    fullname: PJ Kappelle
– volume: 21
  start-page: 238
  year: 1980
  ident: BFnchembio796_CR11
  publication-title: J. Lipid Res.
  doi: 10.1016/S0022-2275(20)39830-8
  contributor:
    fullname: PJ Barter
– volume: 25
  start-page: 1605
  year: 2004
  ident: BFnchembio796_CR26
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20084
  contributor:
    fullname: EF Pettersen
– volume: 6
  start-page: 23
  year: 2004
  ident: BFnchembio796_CR18
  publication-title: Biol. Proced. Online
  doi: 10.1251/bpo70
  contributor:
    fullname: M Ohi
– volume: 323
  start-page: 1234
  year: 1990
  ident: BFnchembio796_CR6
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199011013231803
  contributor:
    fullname: A Inazu
– volume: 51
  start-page: 1228
  year: 2010
  ident: BFnchembio796_CR17
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.D002493
  contributor:
    fullname: L Zhang
– volume: 17
  start-page: 775
  year: 2010
  ident: BFnchembio796_CR28
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1811
  contributor:
    fullname: D Flemming
– volume: 18
  start-page: 921
  year: 2009
  ident: BFnchembio796_CR15
  publication-title: Protein Sci.
  doi: 10.1002/pro.101
  contributor:
    fullname: B Chen
– volume: 45
  start-page: 84
  year: 2011
  ident: BFnchembio796_CR8
  publication-title: Ann. Pharmacother.
  doi: 10.1345/aph.1P446
  contributor:
    fullname: MA Miyares
– volume: 36
  start-page: 231
  year: 2006
  ident: BFnchembio796_CR32
  publication-title: Insect Biochem. Mol. Biol.
  doi: 10.1016/j.ibmb.2006.01.001
  contributor:
    fullname: PM Weers
– volume: 328
  start-page: 183
  year: 2003
  ident: BFnchembio796_CR34
  publication-title: J. Mol. Biol.
  doi: 10.1016/S0022-2836(03)00155-4
  contributor:
    fullname: R Mehta
– volume: 301
  start-page: 369
  year: 2000
  ident: BFnchembio796_CR20
  publication-title: J. Mol. Biol.
  doi: 10.1006/jmbi.2000.3949
  contributor:
    fullname: G Ren
– volume: 62
  start-page: 707
  year: 1977
  ident: BFnchembio796_CR3
  publication-title: Am. J. Med.
  doi: 10.1016/0002-9343(77)90874-9
  contributor:
    fullname: T Gordon
– volume: 34
  start-page: 1255
  year: 1993
  ident: BFnchembio796_CR13
  publication-title: J. Lipid Res.
  doi: 10.1016/S0022-2275(20)36957-1
  contributor:
    fullname: AR Tall
– volume: 116
  start-page: 190
  year: 1996
  ident: BFnchembio796_CR38
  publication-title: J. Struct. Biol.
  doi: 10.1006/jsbi.1996.0030
  contributor:
    fullname: J Frank
– ident: BFnchembio796_CR23
  doi: 10.1007/978-1-349-09857-6_5
– volume: 26
  start-page: 1781
  year: 2005
  ident: BFnchembio796_CR29
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20289
  contributor:
    fullname: JC Phillips
– volume: 48
  start-page: 1481
  year: 2009
  ident: BFnchembio796_CR35
  publication-title: Biochemistry
  doi: 10.1021/bi802287q
  contributor:
    fullname: M Han
– volume: 105
  start-page: 1494
  year: 2008
  ident: BFnchembio796_CR40
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0708667105
  contributor:
    fullname: VE Galkin
– volume: 98
  start-page: 1398
  year: 2001
  ident: BFnchembio796_CR19
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.98.4.1398
  contributor:
    fullname: G Ren
– volume: 263
  start-page: 5150
  year: 1988
  ident: BFnchembio796_CR25
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)60692-1
  contributor:
    fullname: TL Swenson
– volume: 455
  start-page: 109
  year: 2008
  ident: BFnchembio796_CR27
  publication-title: Nature
  doi: 10.1038/nature07159
  contributor:
    fullname: J Liu
– volume: 14
  start-page: 106
  year: 2007
  ident: BFnchembio796_CR10
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb1197
  contributor:
    fullname: X Qiu
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Snippet Optimized negative-staining and cryo–positive staining EM reveals that human cholesteryl ester transfer protein penetrates into HDL and LDL from each distal...
Human cholesteryl ester transfer protein (CETP) mediates the net transfer of cholesteryl ester mass from atheroprotective high-density lipoproteins to...
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proquest
crossref
pubmed
springer
SourceType Open Access Repository
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Index Database
Publisher
StartPage 342
SubjectTerms 631/45/535
631/92/287
631/92/609
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Cardiovascular diseases
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cholesterol Ester Transfer Proteins - chemistry
Cholesterol Ester Transfer Proteins - metabolism
Cryoelectron Microscopy
Density
Humans
Hydrophobic and Hydrophilic Interactions
Lipids
Lipoproteins
Lipoproteins - chemistry
Lipoproteins - metabolism
Lipoproteins, HDL - chemistry
Lipoproteins, HDL - metabolism
Lipoproteins, LDL - chemistry
Lipoproteins, LDL - metabolism
Lipoproteins, VLDL - chemistry
Lipoproteins, VLDL - metabolism
Microscopy, Electron
Models, Molecular
Molecular Dynamics Simulation
Pores
Protein Conformation
Protein Structure, Tertiary
Proteins
Title Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein
URI https://link.springer.com/article/10.1038/nchembio.796
https://www.ncbi.nlm.nih.gov/pubmed/22344176
https://www.proquest.com/docview/1018924239
https://search.proquest.com/docview/929122628
https://pubmed.ncbi.nlm.nih.gov/PMC3792710
Volume 8
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