Identification of adipocyte infiltration-related gene subtypes for predicting colorectal cancer prognosis and responses of immunotherapy/chemotherapy

• Published in: Heliyon Vol. 10; no. 13; p. e33616
• Main Authors: Fu, Daan, Zhang, Tianhao, Liu, Jia, Chang, Bingcheng, Zhang, Qingqing, Tan, Yuyan, Chen, Xiangdong, Tan, Lulu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.07.2024; Elsevier
• Subjects: Adipocyte infiltration; adipocytes; algorithms; Colorectal cancer; colorectal neoplasms; data collection; drug therapy; genes; Immune-associated features; immunotherapy; prediction; Prognosis; Unsupervised clustering; Adipocyte infiltration; Prognosis; Immune-associated features; Colorectal cancer; Unsupervised clustering

Colorectal cancer (CRC) is a prevalent and aggressive malignancy characterized by a complex tumor microenvironment (TME). Given the variations in the level of adipocyte infiltration in TME, the prognosis may differ among CRC patients. Thus, there is an urgent need to establish a reliable method for...