Knockout of PERK protects rat Müller glial cells against OGD-induced endoplasmic reticulum stress-related apoptosis

• Published in: BMC ophthalmology Vol. 23; no. 1; pp. 286 - 11
• Main Authors: Wang, Xiaorui, Zhu, Xinxing, Huang, Guangqian, Wu, Lili, Meng, Zhiyong, Wu, Yuyu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.06.2023; BioMed Central; BMC
• Subjects: Alzheimer's disease; Animals; Apoptosis; Autophagy; Caspase-12; Cells; Cholecystokinin; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Ependymoglial Cells; Eye diseases; Flow cytometry; Glial cells; Glucose; Homeostasis; Hypoxia; Immunofluorescence; Initiation factor eIF-2; Ischemia; Metabolism; Mueller cells; Müller glia; Ophthalmology; Oxygen; Oxygen-glucose deprivation; Pathogenesis; Protein synthesis; Proteins; Rats; Rats, Sprague-Dawley; Reagents; Retina; Signal Transduction; Tau protein; Western blotting; Japan; United States > US; Müller glia; Autophagy; Oxygen-glucose deprivation; Apoptosis; Endoplasmic reticulum stress

The pathological basis for many retinal diseases, retinal ischemia is also one of the most common causes of visual impairment. Numerous ocular diseases have been linked to Endoplasmic reticulum(ER)stress. However, there is still no clear understanding of the relationship between ER stress and Müller...