Safety of combination therapy with two bDMARDs in patients with rheumatoid arthritis: A systematic review and meta-analysis

• Published in: Seminars in arthritis and rheumatism Vol. 49; no. 1; pp. 35 - 42
• Main Authors: Boleto, Gonçalo, Kanagaratnam, Lukshe, Dramé, Moustapha, Salmon, Jean-Hugues
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019; WB Saunders
• Subjects: Antirheumatic Agents - adverse effects; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Biological Products - adverse effects; Biological Products - therapeutic use; Drug therapy, Combination; Drug Therapy, Combination - adverse effects; Drug tolerance; Humans; Life Sciences; Meta-analysis as topic; Rheumatoid arthritis-drug therapy; Treatment Outcome; Rheumatoid arthritis-drug therapy; Meta-analysis as topic; Drug therapy, Combination; Drug tolerance
• ISSN: 0049-0172; 1532-866X; 1532-866X
• DOI: 10.1016/j.semarthrit.2018.12.003

We performed a systematic review and meta-analysis of the current literature to assess the safety of combining two biologic disease-modifying antirheumatic drugs (bDMARDs) in the treatment of rheumatoid arthritis (RA). We systematically searched for controlled studies evaluating safety in patients w...