Higher C-Peptide Level During Glucose Clamp Is Associated With Muscle Insulin Resistance in Nonobese Japanese Men

• Published in: Journal of the Endocrine Society Vol. 3; no. 10; pp. 1847 - 1857
• Main Authors: Kaga, Hideyoshi, Tamura, Yoshifumi, Takeno, Kageumi, Kakehi, Saori, Someya, Yuki, Funayama, Takashi, Furukawa, Yasuhiko, Suzuki, Ruriko, Sugimoto, Daisuke, Kadowaki, Satoshi, Nishitani-Yokoyama, Miho, Shimada, Kazunori, Daida, Hiroyuki, Aoki, Shigeki, Giacca, Adria, Kanazawa, Akio, Kawamori, Ryuzo, Watada, Hirotaka
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.10.2019; Oxford University Press
• Subjects: Clinical s; Glucose; Health aspects; Insulin resistance; Peptides; Japan; nonobese; hyperinsulinemia; insulin resistance; feedback inhibition of insulin secretion

ContextCirculating C-peptide is generally suppressed by exogenous insulin infusion. However, steady-state serum C-peptide (SSSC) levels during hyperinsulinemic-euglycemic clamp in obese subjects are higher than in healthy subjects, which may contribute to hyperinsulinemia to compensate for insulin r...