DNA vaccine protection against SARS-CoV-2 in rhesus macaques - Yu, Jingyou; Tostanoski, Lisa H.; Peter, Lauren; Mercado, Noe B.; McMahan, Katherine; Mahrokhian, Shant H.; Nkolola, Joseph P.; Liu, Jinyan; Li, Zhenfeng; Chandrashekar, Abishek; Martinez, David R.; Loos, Carolin; et al. (Science (American Association for the Advancement of Science), 2020)
Keywords: Adjuvants, Immunologic; Alveoli; Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Betacoronavirus - immunology; Betacoronavirus - physiology; Bronchoalveolar Lavage Fluid - virology; Bronchus; Coronaviridae; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; Coronavirus Infections - virology; Coronaviruses; COVID-19; COVID-19 Vaccines; Deoxyribonucleic acid; Disease Models, Animal; DNA; DNA vaccines; Female; Humans; Immune response (cell-mediated); Immune response (humoral); Immunity, Cellular; Immunity, Humoral; Immunization, Secondary; Immunogenicity, Vaccine; Immunologic Memory; Immunology; Macaca mulatta; Male; Microbio; Mucosa; Mutant Proteins - chemistry; Mutant Proteins - immunology; Nasal Mucosa - virology; Neutralizing; Pandemics; Pandemics - prevention & control; Pneumonia, Viral - immunology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - virology; Primates; Protein Domains; Proteins; Prototypes; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Vaccination; Vaccines; Vaccines, DNA - administration & dosage; Vaccines, DNA - immunology; Viral diseases; Viral Load; Viral Vaccines - administration & dosage; Viral Vaccines - immunology; Viruses