Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease - Dai, Wenhao; Zhang, Bing; Jiang, Xia-Ming; Su, Haixia; Li, Jian; Zhao, Yao; Xie, Xiong; Jin, Zhenming; Peng, Jingjing; Liu, Fengjiang; Li, Chunpu; Li, You; et al. (Science (American Association for the Advancement of Science), 2020)
Keywords: Aldehydes; Animals; Antiviral activity; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Antiviral drugs; Betacoronavirus - drug effects; Betacoronavirus - enzymology; Biochem; Biocompatibility; Catalytic Domain; Cell culture; Chlorocebus aethiops; Coronaviridae; Coronavirus 3C Proteases; Coronavirus Infections - drug therapy; Coronaviruses; COVID-19; Crystal structure; Cysteine Endopeptidases; Dogs; Drug Design; Drug development; Drug Evaluation, Preclinical; Etiology; Female; Humans; Lead compounds; Male; Mice; Molecular Structure; Pandemics; Pharmacokinetics; Pharmacology; Pneumonia, Viral - drug therapy; Protease; Protease inhibitors; Protein Structure, Tertiary; Proteinase inhibitors; Racing; Rats, Sprague-Dawley; Replication; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Therapeutic targets; Toxicity; Toxicity testing; Toxicity Tests; Transcription; Vero Cells; Viral diseases; Viral Nonstructural Proteins - antagonists & inhibitors; Viruses