Modulation of the Mucosa-Associated Microbiome Linked to the PTPN2 Risk Gene in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis

• Published in: Microorganisms (Basel) Vol. 9; no. 8; p. 1752
• Main Authors: Denoth, Luisa, Juillerat, Pascal, Kremer, Andreas E., Rogler, Gerhard, Scharl, Michael, Yilmaz, Bahtiyar, Bluemel, Sena
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 17.08.2021; MDPI
• Subjects: Abundance; Actinobacillus; Bacteroides; Bifidobacterium; Biopsy; Brachyspira; Cholangitis; Colon; Data collection; Dysbacteriosis; dysbiosis; Ethics; Fusobacterium; genes; Haemophilus; Ileum; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Intestinal microflora; intestinal microorganisms; Liver diseases; microbiome; Microbiomes; Microbiota; Microorganisms; Mucosa; mucosa-associated microbiome; Pathogenesis; Patients; Protein-tyrosine-phosphatase; PSC; PTPN2; PTPN2 protein; rectum; Relative abundance; risk; Roseburia; rRNA 16S; Small intestine; Taxonomy; TCPTP; Tepidimonas; Tyrosine; Ulcerative colitis; United States > US; Germany

Gut microbiota appears to be involved in the pathogenesis of primary sclerosing cholangitis (PSC). The protein tyrosine phosphatase nonreceptor 2 (PTPN2) gene risk variant rs1893217 is associated with gut dysbiosis in inflammatory bowel disease (IBD), and PTPN2 was mentioned as a possible risk gene...