Expression and functional characterisation of natural R147W and K150del variants of protein C in the Chinese population

• Published in: Thrombosis and haemostasis Vol. 109; no. 4; p. 614
• Main Authors: Ding, Qiulan, Yang, Likui, Hassanian, Seyed Mahdi, Rezaie, A R
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2013
• Subjects: Antigens, CD - metabolism; Asian Continental Ancestry Group - genetics; Blood Coagulation - genetics; China - epidemiology; Endothelial Cells - metabolism; Endothelial Protein C Receptor; Gene Frequency; Genetic Predisposition to Disease; HEK293 Cells; Humans; Kinetics; Mutation; Phenotype; Protein Binding; Protein C - genetics; Protein C - metabolism; Protein C Deficiency - blood; Protein C Deficiency - ethnology; Protein C Deficiency - genetics; Receptors, Cell Surface - metabolism; Signal Transduction; Transfection; Venous Thrombosis - blood; Venous Thrombosis - ethnology; Venous Thrombosis - genetics

Protein C is a vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (APC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa. In addition to its anticoagulant activity, APC also exhibits pote...