Autoantibody Cancer Biomarker: Extracellular Protein Kinase A

• Published in: Cancer research (Chicago, Ill.) Vol. 66; no. 18; pp. 8971 - 8974
• Main Authors: Nesterova, Maria V., Johnson, Natalie, Cheadle, Christopher, Bates, Susan E., Mani, Sridhar, Stratakis, Constantine A., Kahn, Islam, Gupta, Rishab K., Cho-Chung, Yoon S.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.09.2006
• Subjects: Antibodies, Anti-Idiotypic - blood; Antineoplastic agents; Autoantibodies - blood; Biological and medical sciences; Cyclic AMP-Dependent Protein Kinases - immunology; Humans; Immunoenzyme Techniques - methods; Medical sciences; Neoplasms - blood; Neoplasms - enzymology; Neoplasms - immunology; Pharmacology. Drug treatments; Tumors; Autoimmunity; Protein kinase A; Antibody; Autoantibody; Biological marker; Malignant tumor; cAMP-dependent protein kinase; Extracellular; Cancer

In cancer cells, cyclic AMP–dependent protein kinase (PKA) is secreted into the conditioned medium. This PKA, designated as extracellular protein kinase A (ECPKA), is markedly up-regulated in the sera of patients with cancer. The currently available tumor markers are based on the antigen determinati...