De novo design of picomolar SARS-CoV-2 miniprotein inhibitors - Cao, Longxing; Goreshnik, Inna; Coventry, Brian; Case, James Brett; Miller, Lauren; Kozodoy, Lisa; Chen, Rita E.; Carter, Lauren; Walls, Alexandra C.; Park, Young-Jun; Strauch, Eva-Maria; Stewart, Lance; et al. (Science (American Association for the Advancement of Science), 2020)
Keywords: ACE2; Affinity; Amino Acid Sequence; Amino acids; Anatomy; Angiotensin; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents - chemistry; Betacoronavirus - drug effects; Binding; Binding Sites; Biochem; Cell size; Chlorocebus aethiops; Computer applications; Coronaviridae; Coronavirus Infections; Coronaviruses; COVID-19; Cryoelectron Microscopy; Design; Drug Design; Electron microscopy; Enzymes; Immunotherapy; Inhibitors; Mammalian cells; Mammals; Mathematical models; Microscopy; Molec Biol; Molecular Docking Simulation; Monoclonal antibodies; Pandemics; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - chemistry; Pneumonia, Viral; Protein Binding - drug effects; Proteins; Receptors; Respiratory diseases; Respiratory system; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - antagonists & inhibitors; Spike Glycoprotein, Coronavirus - chemistry; Spike protein; Stability; Trimers; Vero Cells; Viral diseases