Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

• Published in: Science (American Association for the Advancement of Science) Vol. 370; no. 6519; pp. 950 - 957
• Main Authors: Tortorici, M. Alejandra, Beltramello, Martina, Lempp, Florian A., Pinto, Dora, Dang, Ha V., Rosen, Laura E., McCallum, Matthew, Bowen, John, Minola, Andrea, Jaconi, Stefano, Zatta, Fabrizia, De Marco, Anna, Guarino, Barbara, Bianchi, Siro, Lauron, Elvin J., Tucker, Heather, Zhou, Jiayi, Peter, Alessia, Havenar-Daughton, Colin, Wojcechowskyj, Jason A., Case, James Brett, Chen, Rita E., Kaiser, Hannah, Montiel-Ruiz, Martin, Meury, Marcel, Czudnochowski, Nadine, Spreafico, Roberto, Dillen, Josh, Ng, Cindy, Sprugasci, Nicole, Culap, Katja, Benigni, Fabio, Abdelnabi, Rana, Foo, Shi-Yan Caroline, Schmid, Michael A., Cameroni, Elisabetta, Riva, Agostino, Gabrieli, Arianna, Galli, Massimo, Pizzuto, Matteo S., Neyts, Johan, Diamond, Michael S., Virgin, Herbert W., Snell, Gyorgy, Corti, Davide, Fink, Katja, Veesler, David
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 20.11.2020; American Association for the Advancement of Science
• Subjects: ACE2; Amino Acid Motifs - immunology; Angiotensin-Converting Enzyme 2; Animals; Antibodies; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - isolation & purification; Antibodies, Viral - administration & dosage; Antibodies, Viral - immunology; Antibodies, Viral - isolation & purification; Betacoronavirus - immunology; Biochem; CHO Cells; Coronaviridae; Coronavirus Infections - prevention & control; Coronavirus Infections - therapy; Coronaviruses; COVID-19; Cricetinae; Cricetulus; Cryoelectron Microscopy; Electron microscopy; Epitopes; HEK293 Cells; Humans; Immunodominant Epitopes - chemistry; Immunodominant Epitopes - immunology; Immunology; Microscopy; Microscopy, Electron; Pandemics - prevention & control; Peptidyl-Dipeptidase A - immunology; Pneumonia, Viral - prevention & control; Pneumonia, Viral - therapy; Prophylaxis; Protein Domains - immunology; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - antagonists & inhibitors; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Viral infections

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by the trimeric spike protein that decorates the virus and binds the ACE2 receptor. Antibodies against the spike that neutralize viral infection have potential as therapeutics. Tortorici et al. describe two very pote...