The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

• Published in: The FASEB journal Vol. 31; no. 1; p. 85
• Main Authors: Alvarado, Raquel, To, Joyce, Lund, Maria E, Pinar, Anita, Mansell, Ashley, Robinson, Mark W, O'Brien, Bronwyn A, Dalton, John P, Donnelly, Sheila
• Format: Journal Article
• Language: English
• Published: United States 01.01.2017
• Subjects: Animals; Cathepsin B - genetics; Cathepsin B - metabolism; Cytokines - genetics; Cytokines - metabolism; Fasciola hepatica - genetics; Fasciola hepatica - metabolism; Gene Expression Regulation - physiology; Helminth Proteins - genetics; Helminth Proteins - metabolism; Hydrogen-Ion Concentration; Lysosomes - metabolism; Macrophages - drug effects; Macrophages - physiology; Mice; Mice, Inbred BALB C; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Silicon Dioxide - toxicity; liver fluke; IL-1β; trematode; lysosome

The NLRP3 inflammasome is a multimeric protein complex that controls the production of IL-1β, a cytokine that influences the development of both innate and adaptive immune responses. Helminth parasites secrete molecules that interact with innate immune cells, modulating their activity to ultimately...