Association of asthma genetic variants with asthma‐associated traits reveals molecular pathways of eosinophilic asthma

• Published in: Clinical and translational allergy Vol. 13; no. 4; pp. e12239 - n/a
• Main Authors: El‐Husseini, Zaid W., Vonk, Judith M., Berge, Maarten, Gosens, Reinoud, Koppelman, Gerard H.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2023; John Wiley and Sons Inc; Wiley
• Subjects: Airway management; Asthma; asthma heterogeneity; Disease; Drugs; endotype; Gene expression; genome wide association; Genomes; Original; phenotype; Proteins; Regression analysis; single nucleotide polymorphism; phenotype; asthma heterogeneity; endotype; single nucleotide polymorphism; genome wide association

Introduction Asthma is a complex, polygenic, heterogenous inflammatory disease. Recently, we generated a list of 128 independent single nucleotide polymorphisms (SNPs) associated with asthma in genome‐wide association studies. However, it is unknown if asthma SNPs are associated with specific asthma...