Genetic interplay between human longevity and metabolic pathways — a large‐scale eQTL study

• Published in: Aging cell Vol. 16; no. 4; pp. 716 - 725
• Main Authors: Häsler, Robert, Venkatesh, Geetha, Tan, Qihua, Flachsbart, Friederike, Sinha, Anupam, Rosenstiel, Philip, Lieb, Wolfgang, Schreiber, Stefan, Christensen, Kaare, Christiansen, Lene, Nebel, Almut
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2017; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Analysis; Denmark; functional genomics; Genes; Genetic aspects; Genetic research; Genetic transcription; Genome, Human; Genotype; Germany; Heritability; High-Throughput Nucleotide Sequencing; human; Humans; Longevity; Longevity - genetics; Longitudinal Studies; Metabolic Networks and Pathways - genetics; Metabolic pathways; Metabolism; Middle Aged; Original; Physiological aspects; Polymorphism, Single Nucleotide; Quantitative genetics; Quantitative Trait Loci; Quantitative Trait, Heritable; Ribonucleic acid; RNA; RNA sequencing; Transcription; Transcriptome; Twins; Twins, Dizygotic; Twins, Monozygotic; longevity; functional genomics; RNA- sequencing; human; transcriptome

Summary Human longevity is a complex phenotype influenced by genetic and environmental components. Unraveling the contribution of genetic vs. nongenetic factors to longevity is a challenging task. Here, we conducted a large‐scale RNA‐sequencing‐based expression quantitative trait loci study (eQTL) w...