Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia

• Published in: Journal of clinical pharmacology Vol. 42; no. 1; p. 70
• Main Authors: Wallace, Mark S, Ridgeway, 3rd, Beri, Leung, Albert, Schulteis, Gery, Yaksh, Tony L
• Format: Journal Article
• Language: English
• Published: England 01.01.2002
• Subjects: Adult; Alfentanil - administration & dosage; Alfentanil - blood; Analgesics - administration & dosage; Analgesics - adverse effects; Analgesics - blood; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - blood; Analysis of Variance; Capsaicin - adverse effects; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia - chemically induced; Hyperalgesia - drug therapy; Hyperalgesia - physiopathology; Infusions, Intravenous; Ketamine - administration & dosage; Ketamine - adverse effects; Ketamine - blood; Male; Middle Aged; Pain Threshold - drug effects; Pain Threshold - physiology; Touch

The authors have extended preclinical studies on pain to human volunteers by examining the effects of intravenous alfentanil and ketamine on acute sensory thresholds andfacilitated processing induced by intradermal capsaicin. Eleven healthy subjects received targeted plasma concentrations of alfenta...