Functional Liver Cell–Based Platforms in Biomedical Research

• Published in: PHARMACOLOGY RESEARCH & PERSPECTIVES Vol. 13; no. 3; pp. e70128 - n/a
• Main Authors: Hashemian, Zohreh, Taleahmad, Sara, Shokouhian, Bahare, Najimi, Mustapha, Vosough, Massoud
• Format: Journal Article Publication
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2025; John Wiley and Sons Inc; Wiley
• Subjects: Animals; biomedical research; Biomedical Research - methods; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Coculture Techniques - methods; Drug development; Drug Evaluation, Preclinical - methods; drug screening platforms; hepatocytes; Hepatocytes - cytology; Hepatocytes - metabolism; hepatoma cells; Humans; improved metabolic performance; Liver - cytology; Liver - metabolism; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Metabolites; Review; Stem cells; Toxicity; drug screening platforms; improved metabolic performance; hepatocytes; hepatoma cells; biomedical research

ABSTRACT Recapitulating in vivo conditions of metabolism remains a challenging subject in biomedical research such as ADME‐Tox assays (absorption, distribution, metabolism, excretion, and toxicity). The advanced technologies using 3D co‐culture methods enabled researchers to develop cell–cell and ce...