Endothelins contribute towards nociception induced by antigen in ovalbumin‐sensitised mice

• Published in: British journal of pharmacology Vol. 141; no. 4; pp. 755 - 763
• Main Authors: Piovezan, Anna P, D'Orléans‐Juste, Pedro, Frighetto, Monica, Souza, Glória E P, Henriques, Maria G M O, Rae, Giles A
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2004; Nature Publishing
• Subjects: allergy; Animals; antigen; Antigens - immunology; Antigens - pharmacology; Biological and medical sciences; Dose-Response Relationship, Drug; Endothelin; Endothelins - physiology; Hyperalgesia - physiopathology; Hypersensitivity - physiopathology; Indicators and Reagents; inflammation; Male; Medical sciences; Mice; nociception; Oligopeptides - pharmacology; ovalbumin; Ovalbumin - immunology; Ovalbumin - pharmacology; p-Methoxy-N-methylphenethylamine - pharmacology; pain; Pain - physiopathology; Peptides, Cyclic - pharmacology; Pharmacology. Drug treatments; Piperidines - pharmacology; Sulfonamides - pharmacology; Viper Venoms - pharmacology; Nociception; Immunopathology; Allergy; Endothelin; Rodentia; Inflammation; antigen; Vertebrata; Mammalia; Pain; Mouse; Animal; ovalbumin

The contribution of endogenous endothelins to nociceptive responses elicited by ovalbumin (OVA) in the hind‐paw of mice sensitised to this antigen (50 μg OVA+5 mg Al(OH)3, s.c., 14 days beforehand) was investigated. Sensitised mice exhibited greater nocifensive responsiveness to intraplantar (i.pl.)...