Patient‐derived organoid models help define personalized management of gastrointestinal cancer

• Published in: British journal of surgery Vol. 105; no. 2; pp. e48 - e60
• Main Authors: Aberle, M. R., Burkhart, R. A., Tiriac, H., Olde Damink, S. W. M., Dejong, C. H. C., Tuveson, D. A., van Dam, R. M.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.2018; Oxford University Press
• Subjects: Cancer therapies; Cell Culture Techniques - methods; Gastrointestinal Neoplasms - therapy; Humans; Medical prognosis; Models, Anatomic; Organoids; Precision Medicine - methods; Review

Background The prognosis of patients with different gastrointestinal cancers varies widely. Despite advances in treatment strategies, such as extensive resections and the addition of new drugs to chemotherapy regimens, conventional treatment strategies have failed to improve survival for many tumour...