Atrophy of specific amygdala subfields in subjects converting to mild cognitive impairment
Introduction Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairme...
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| Published in | Alzheimer's & dementia : translational research & clinical interventions Vol. 9; no. 4; pp. e12436 - n/a |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
John Wiley & Sons, Inc
01.10.2023
John Wiley and Sons Inc Wiley |
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| Online Access | Get full text |
| ISSN | 2352-8737 2352-8737 |
| DOI | 10.1002/trc2.12436 |
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| Abstract | Introduction
Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI).
Methods
Our sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow‐up: 75 who remained stable (s‐HC) and 22 who converted to MCI within 48 months (c‐HC). Anatomical magnetic resonance (MR) images were analyzed using a semi‐automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quantitative structural metrics for different amygdala subfields in each participant. Spearman's correlations were performed between MR measures and baseline and longitudinal neuropsychological measures. We also included anatomical measurements of the whole amygdala, the hippocampus, a key target of AD‐related pathology, and the whole cortical thickness as a test of spatial specificity.
Results
Compared with s‐HC individuals, c‐HC subjects showed a reduced right amygdala volume, whereas no significant difference was observed for hippocampal volumes or changes in cortical thickness. In the amygdala subfields, we observed selected atrophy patterns in the basolateral nuclear complex, anterior amygdala area, and transitional area. Macro‐structural alterations in these subfields correlated with variations of global indices of cognitive performance (measured at baseline and the 48‐month follow‐up), suggesting that amygdala changes shape the cognitive progression to MCI.
Discussion
Our results provide anatomical evidence for the early involvement of the amygdala in the preclinical stages of AD.
Highlights
Amygdala's atrophy marks elderly progression to mild cognitive impairment (MCI).
Amygdala's was observed within the basolateral and amygdaloid complexes.
Macro‐structural alterations were associated with cognitive decline.
No atrophy was found in the hippocampus and cortex. |
|---|---|
| AbstractList | IntroductionAccumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI).MethodsOur sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow-up: 75 who remained stable (s-HC) and 22 who converted to MCI within 48 months (c-HC). Anatomical magnetic resonance (MR) images were analyzed using a semi-automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quantitative structural metrics for different amygdala subfields in each participant. Spearman's correlations were performed between MR measures and baseline and longitudinal neuropsychological measures. We also included anatomical measurements of the whole amygdala, the hippocampus, a key target of AD-related pathology, and the whole cortical thickness as a test of spatial specificity.ResultsCompared with s-HC individuals, c-HC subjects showed a reduced right amygdala volume, whereas no significant difference was observed for hippocampal volumes or changes in cortical thickness. In the amygdala subfields, we observed selected atrophy patterns in the basolateral nuclear complex, anterior amygdala area, and transitional area. Macro-structural alterations in these subfields correlated with variations of global indices of cognitive performance (measured at baseline and the 48-month follow-up), suggesting that amygdala changes shape the cognitive progression to MCI.DiscussionOur results provide anatomical evidence for the early involvement of the amygdala in the preclinical stages of AD.HighlightsAmygdala's atrophy marks elderly progression to mild cognitive impairment (MCI).Amygdala's was observed within the basolateral and amygdaloid complexes.Macro-structural alterations were associated with cognitive decline.No atrophy was found in the hippocampus and cortex. Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI). Our sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow-up: 75 who remained stable (s-HC) and 22 who converted to MCI within 48 months (c-HC). Anatomical magnetic resonance (MR) images were analyzed using a semi-automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quantitative structural metrics for different amygdala subfields in each participant. Spearman's correlations were performed between MR measures and baseline and longitudinal neuropsychological measures. We also included anatomical measurements of the whole amygdala, the hippocampus, a key target of AD-related pathology, and the whole cortical thickness as a test of spatial specificity. Compared with s-HC individuals, c-HC subjects showed a reduced right amygdala volume, whereas no significant difference was observed for hippocampal volumes or changes in cortical thickness. In the amygdala subfields, we observed selected atrophy patterns in the basolateral nuclear complex, anterior amygdala area, and transitional area. Macro-structural alterations in these subfields correlated with variations of global indices of cognitive performance (measured at baseline and the 48-month follow-up), suggesting that amygdala changes shape the cognitive progression to MCI. Our results provide anatomical evidence for the early involvement of the amygdala in the preclinical stages of AD. Amygdala's atrophy marks elderly progression to mild cognitive impairment (MCI).Amygdala's was observed within the basolateral and amygdaloid complexes.Macro-structural alterations were associated with cognitive decline.No atrophy was found in the hippocampus and cortex. Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI).IntroductionAccumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI).Our sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow-up: 75 who remained stable (s-HC) and 22 who converted to MCI within 48 months (c-HC). Anatomical magnetic resonance (MR) images were analyzed using a semi-automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quantitative structural metrics for different amygdala subfields in each participant. Spearman's correlations were performed between MR measures and baseline and longitudinal neuropsychological measures. We also included anatomical measurements of the whole amygdala, the hippocampus, a key target of AD-related pathology, and the whole cortical thickness as a test of spatial specificity.MethodsOur sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow-up: 75 who remained stable (s-HC) and 22 who converted to MCI within 48 months (c-HC). Anatomical magnetic resonance (MR) images were analyzed using a semi-automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quantitative structural metrics for different amygdala subfields in each participant. Spearman's correlations were performed between MR measures and baseline and longitudinal neuropsychological measures. We also included anatomical measurements of the whole amygdala, the hippocampus, a key target of AD-related pathology, and the whole cortical thickness as a test of spatial specificity.Compared with s-HC individuals, c-HC subjects showed a reduced right amygdala volume, whereas no significant difference was observed for hippocampal volumes or changes in cortical thickness. In the amygdala subfields, we observed selected atrophy patterns in the basolateral nuclear complex, anterior amygdala area, and transitional area. Macro-structural alterations in these subfields correlated with variations of global indices of cognitive performance (measured at baseline and the 48-month follow-up), suggesting that amygdala changes shape the cognitive progression to MCI.ResultsCompared with s-HC individuals, c-HC subjects showed a reduced right amygdala volume, whereas no significant difference was observed for hippocampal volumes or changes in cortical thickness. In the amygdala subfields, we observed selected atrophy patterns in the basolateral nuclear complex, anterior amygdala area, and transitional area. Macro-structural alterations in these subfields correlated with variations of global indices of cognitive performance (measured at baseline and the 48-month follow-up), suggesting that amygdala changes shape the cognitive progression to MCI.Our results provide anatomical evidence for the early involvement of the amygdala in the preclinical stages of AD.DiscussionOur results provide anatomical evidence for the early involvement of the amygdala in the preclinical stages of AD.Amygdala's atrophy marks elderly progression to mild cognitive impairment (MCI).Amygdala's was observed within the basolateral and amygdaloid complexes.Macro-structural alterations were associated with cognitive decline.No atrophy was found in the hippocampus and cortex.HighlightsAmygdala's atrophy marks elderly progression to mild cognitive impairment (MCI).Amygdala's was observed within the basolateral and amygdaloid complexes.Macro-structural alterations were associated with cognitive decline.No atrophy was found in the hippocampus and cortex. Introduction Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI). Methods Our sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow‐up: 75 who remained stable (s‐HC) and 22 who converted to MCI within 48 months (c‐HC). Anatomical magnetic resonance (MR) images were analyzed using a semi‐automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quantitative structural metrics for different amygdala subfields in each participant. Spearman's correlations were performed between MR measures and baseline and longitudinal neuropsychological measures. We also included anatomical measurements of the whole amygdala, the hippocampus, a key target of AD‐related pathology, and the whole cortical thickness as a test of spatial specificity. Results Compared with s‐HC individuals, c‐HC subjects showed a reduced right amygdala volume, whereas no significant difference was observed for hippocampal volumes or changes in cortical thickness. In the amygdala subfields, we observed selected atrophy patterns in the basolateral nuclear complex, anterior amygdala area, and transitional area. Macro‐structural alterations in these subfields correlated with variations of global indices of cognitive performance (measured at baseline and the 48‐month follow‐up), suggesting that amygdala changes shape the cognitive progression to MCI. Discussion Our results provide anatomical evidence for the early involvement of the amygdala in the preclinical stages of AD. Highlights Amygdala's atrophy marks elderly progression to mild cognitive impairment (MCI). Amygdala's was observed within the basolateral and amygdaloid complexes. Macro‐structural alterations were associated with cognitive decline. No atrophy was found in the hippocampus and cortex. Abstract Introduction Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI). Methods Our sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow‐up: 75 who remained stable (s‐HC) and 22 who converted to MCI within 48 months (c‐HC). Anatomical magnetic resonance (MR) images were analyzed using a semi‐automatic approach that combines probabilistic methods and a priori information from ex vivo MR images and histology to segment and obtain quantitative structural metrics for different amygdala subfields in each participant. Spearman's correlations were performed between MR measures and baseline and longitudinal neuropsychological measures. We also included anatomical measurements of the whole amygdala, the hippocampus, a key target of AD‐related pathology, and the whole cortical thickness as a test of spatial specificity. Results Compared with s‐HC individuals, c‐HC subjects showed a reduced right amygdala volume, whereas no significant difference was observed for hippocampal volumes or changes in cortical thickness. In the amygdala subfields, we observed selected atrophy patterns in the basolateral nuclear complex, anterior amygdala area, and transitional area. Macro‐structural alterations in these subfields correlated with variations of global indices of cognitive performance (measured at baseline and the 48‐month follow‐up), suggesting that amygdala changes shape the cognitive progression to MCI. Discussion Our results provide anatomical evidence for the early involvement of the amygdala in the preclinical stages of AD. Highlights Amygdala's atrophy marks elderly progression to mild cognitive impairment (MCI). Amygdala's was observed within the basolateral and amygdaloid complexes. Macro‐structural alterations were associated with cognitive decline. No atrophy was found in the hippocampus and cortex. |
| Author | Baldassarre, Antonello Padulo, Caterina Onofrj, Marco Granzotto, Alberto Ferretti, Antonio Sestieri, Carlo Sensi, Stefano L. Delli Pizzi, Stefano Chiacchiaretta, Piero Tullo, Maria Giulia Punzi, Miriam Picerni, Eleonora |
| AuthorAffiliation | 5 Department of Innovative Technologies in Medicine and Dentistry “G. d'Annunzio” University of Chieti‐Pescara, Chieti Chieti Italy 4 Molecular Neurology Unit Center for Advanced Studies and Technology (CAST) University “G. d'Annunzio” of Chieti‐Pescara Chieti Italy 1 Department of Neuroscience, Imaging, and Clinical Sciences University “G. d'Annunzio” of Chieti‐Pescara Chieti Italy 3 Institute for Advanced Biomedical Technologies (ITAB) “G. d'Annunzio” University, Chieti‐Pescara Chieti Italy 2 Department of Humanities University of Naples Federico II Naples Italy 6 Advanced Computing Core Center for Advanced Studies and Technology (CAST) University “G. d'Annunzio” of Chieti‐Pescara Chieti Italy |
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| Cites_doi | 10.1016/j.neurobiolaging.2019.07.005 10.1002/alz.046762 10.1002/hbm.23289 10.2174/1567205017666201203085524 10.1212/WNL.0000000000005303 10.1212/01.wnl.0000336925.79704.9f 10.1177/0891988719882102 10.1002/path.2565 10.1002/ana.20100 10.1038/s41467-020-15701-2 10.1097/NEN.0b013e31816a1df3 10.1093/brain/awy132 10.1016/0306-4522(90)90408-V 10.1212/WNL.0b013e31820d62d9 10.1016/j.cub.2007.08.005 10.1016/00223956(82)900334 10.1093/brain/aww243 10.1097/00002093-199700112-00003 10.1016/j.neurobiolaging.2014.06.032 10.1002/hbm.25216 10.1176/ajp.156.2.216 10.1016/j.pscychresns.2011.06.014 10.1002/(SICI)1096-9861(19970324)379:4<482::AID-CNE2>3.0.CO;2-Z 10.1016/j.jalz.2016.11.006 10.1093/geronj/37.3.323 10.1016/j.neuroimage.2013.05.007 10.1002/jmri.26037 10.3233/JAD-220228 10.1017/S1366728911000332 10.1016/j.neuroimage.2017.04.046 10.2174/1567205011666140131123653 10.1111/bpa.12289 10.1016/j.nicl.2023.103374 10.1002/cne.23415 10.1016/j.nlm.2014.02.005 10.1093/jnen/nlx099 10.1016/j.neulet.2022.136958 10.1016/j.neuroimage.2008.12.033 10.1002/gps.3992 10.3389/fnagi.2017.00050 10.1016/j.nicl.2016.12.011 10.1007/s11682-020-00366-8 10.1016/j.pscychresns.2006.01.007 10.1038/nrneurol.2015.250 10.1093/brain/awv236 10.1016/j.neurobiolaging.2018.10.004 10.1212/WNL.0000000000001171 |
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| Copyright | 2023 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association. 2023. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Notes | Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in the analysis or writing of this report. A complete listing of ADNI investigators can be found at http://adni.loni.usc.edu/wp‐content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Data used in preparation of this article were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in the analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp‐content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf |
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| References | 2009; 45 2015; 36 1982; 17 2023; 38 2020; 17 2020; 16 2013; 521 2014; 29 2020; 11 2012; 15 2017; 155 2011; 194 2008; 71 2016; 37 2017; 9 1997; 11 2015; 138 2015; 84 1987 2008; 67 2018; 77 2014; 11 1989 2007; 17 2018; 141 1997; 379 1982; 37 2021; 42 1990; 37 2019; 74 2023; 15 2013; 83 1998 2022; 89 2011; 76 2020; 33 2009; 219 2016; 12 2014; 112 2004; 55 2021; 15 2019; 82 2017; 13 2023; 792 1964 2019; 49 2018; 90 2016; 139 1999; 156 2016; 26 2006; 146 e_1_2_8_28_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_5_1 e_1_2_8_7_1 e_1_2_8_9_1 Wechsler D (e_1_2_8_23_1) 1987 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_45_1 Kepp KP (e_1_2_8_3_1) 2023; 15 e_1_2_8_41_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_15_1 e_1_2_8_38_1 Morris JC (e_1_2_8_24_1) 1989 e_1_2_8_32_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_53_1 e_1_2_8_51_1 e_1_2_8_30_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_48_1 e_1_2_8_2_1 e_1_2_8_4_1 e_1_2_8_6_1 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_44_1 e_1_2_8_40_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 Rey A (e_1_2_8_22_1) 1964 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_12_1 e_1_2_8_33_1 Spreen O (e_1_2_8_27_1) 1998 e_1_2_8_52_1 e_1_2_8_50_1 |
| References_xml | – volume: 37 start-page: 323 issue: 3 year: 1982 end-page: 329 article-title: Measurement of functional activities in older adults in the community publication-title: J Gerontol – volume: 67 start-page: 309 year: 2008 end-page: 318 article-title: Cholinergic neuronal and axonal abnormalities are present early in aging and in Alzheimer's disease publication-title: J Neuropathol Exp Neurol – volume: 84 start-page: 313 issue: 3 year: 2015 end-page: 324 article-title: The amygdala: functional organization and involvement in neurologic disorders publication-title: Neurology – volume: 76 start-page: 727 issue: 8 year: 2011 end-page: 733 article-title: Local amygdala structural differences with 3T MRI in patients with Alzheimer's disease publication-title: Neurology – volume: 15 year: 2023 article-title: The amyloid cascade hypothesis: an updated critical review publication-title: Brain – volume: 90 start-page: 695 issue: 15 year: 2018 end-page: 703 article-title: Resistance vs resilience to Alzheimer disease: clarifying terminology for preclinical studies publication-title: Neurology – volume: 379 start-page: 482 year: 1997 end-page: 494 article-title: Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer disease publication-title: J Comp Neurol – volume: 13 start-page: 783 issue: 7 year: 2017 end-page: 791 article-title: Sleep changes without medial temporal lobe or brain cortical changes in community‐dwelling individuals with subjective cognitive decline publication-title: Alzheimers Dement – volume: 71 start-page: 1986 issue: 24 year: 2008 end-page: 1992 article-title: Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease publication-title: Neurology – volume: 13 start-page: 415 year: 2017 end-page: 427 article-title: Alzheimer's Disease Neuroimaging Initiative. Rey's Auditory Verbal Learning Test scores can be predicted from whole brain MRI in Alzheimer's disease publication-title: NeuroImage Clin – volume: 11 start-page: 239 issue: 3 year: 2014 end-page: 252 article-title: Amygdalar atrophy in early Alzheimer's disease publication-title: Curr Alzheimer Res – volume: 146 start-page: 251 issue: 3 year: 2006 end-page: 261 article-title: Volumetry of amygdala and hippocampus and memory performance in Alzheimer's disease publication-title: Psychiatry Res Neuroimaging – volume: 26 start-page: 371 issue: 3 year: 2016 end-page: 386 article-title: Precortical phase of Alzheimer's disease (AD)‐related tau cytoskeletal pathology publication-title: Brain Pathol – volume: 139 start-page: 3253 issue: 12 year: 2016 end-page: 3266 article-title: Alzheimer's Disease Neuroimaging Initiative. Whole‐brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala publication-title: Brain – volume: 74 start-page: 21 year: 2019 end-page: 37 article-title: Alzheimer's Disease Neuroimaging Initiative. Functional signature of conversion of patients with mild cognitive impairment publication-title: Neurobiol Aging – year: 1998 – volume: 12 start-page: 131 issue: 3 year: 2016 end-page: 132 article-title: The rising global tide of cognitive impairment publication-title: Nat Rev Neurol – volume: 89 start-page: 233 issue: 1 year: 2022 end-page: 245 article-title: The neuroanatomic correlates of olfactory identification impairment in healthy older adults and in persons with mild cognitive impairment publication-title: J Alzheimer's Dis – volume: 521 start-page: 4124 year: 2013 end-page: 4144 article-title: Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease publication-title: J Comp Neurol – volume: 15 start-page: 1728 issue: 4 year: 2021 end-page: 1738 article-title: Alzheimer's Disease Neuroimaging Initiative. Predicting Alzheimer's conversion in mild cognitive impairment patients using longitudinal neuroimaging and clinical markers publication-title: Brain Imaging Behav – volume: 49 start-page: 152 issue: 1 year: 2019 end-page: 163 article-title: Age‐related changes in cortical and subcortical structures of healthy adult brains: A surface‐based morphometry study publication-title: J Magn Reson Imaging – volume: 33 start-page: 7384 issue: 2 year: 2020 article-title: The Neuropsychiatric Inventory: Development and Applications publication-title: J Geriatr Psychiatry Neurol – volume: 36 start-page: S3 year: 2015 end-page: S10 article-title: Amygdalar atrophy in symptomatic Alzheimer's disease based on diffeomorphometry: the BIOCARD cohort publication-title: Neurobiol Aging – volume: 29 start-page: 127 year: 2014 end-page: 136 article-title: Multiple clock drawing scoring systems: simpler is better publication-title: Int J Geriatr Psychiatry – volume: 194 start-page: 7 issue: 1 year: 2011 end-page: 13 article-title: Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity publication-title: Psychiatry Res Neuroimaging – volume: 17 start-page: R868 issue: 20 year: 2007 end-page: R874 article-title: The amygdala publication-title: Curr Biol – volume: 42 start-page: 192 issue: 1 year: 2021 end-page: 203 article-title: Prediction of 7‐year conversion from subjective cognitive decline to mild cognitive impairment publication-title: Hum Brain Mapp – volume: 82 start-page: 110 year: 2019 end-page: 119 article-title: Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults publication-title: Neurobiol Aging – volume: 17 start-page: 790 issue: 9 year: 2020 end-page: 804 article-title: Acting before: a combined strategy to counteract the onset and progression of dementia publication-title: Curr Alzheimer Res – volume: 141 start-page: 1917 issue: 7 year: 2018 end-page: 1933 article-title: The cholinergic system in the pathophysiology and treatment of Alzheimer's disease publication-title: Brain – volume: 15 start-page: 594 issue: 3 year: 2012 end-page: 615 article-title: Self‐ratings of spoken language dominance: a multilingual naming test (MINT) and preliminary norms for young and aging Spanish‐English bilinguals publication-title: Biling Lang Cogn – volume: 55 start-page: 815 year: 2004 end-page: 828 article-title: Cholinergic nucleus basalis tauopathy emerges early in the aging‐MCI‐AD continuum publication-title: Ann Neurol – year: 1964 – volume: 219 start-page: 41 year: 2009 end-page: 51 article-title: Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease publication-title: J Pathol – volume: 155 start-page: 370 year: 2017 end-page: 382 article-title: High‐resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas publication-title: NeuroImage – year: 1987 – volume: 11 start-page: S13 year: 1997 end-page: S21 article-title: Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study publication-title: Alzheimer Dis Assoc Disord. – start-page: 39 year: 1989 article-title: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease publication-title: Neurology – volume: 45 start-page: 855 year: 2009 end-page: 866 article-title: A comparison of automated segmentation and m anual tracing for quantifying hippocampal and amygdala volumes publication-title: Neuroimage – volume: 16 year: 2020 article-title: Amygdala tau in preclinical Alzheimer's disease: neuroimaging/normal brain aging publication-title: Alzheimers Dement – volume: 9 start-page: 50 year: 2017 article-title: Hippocampal and amygdala gray matter loss in elderly controls with subtle cognitive decline publication-title: Front Aging Neurosci – volume: 11 start-page: 2612 year: 2020 article-title: Alzheimer's Disease Neuroimaging Initiative; Swedish BioFinder Study. Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease publication-title: Nat Commun – volume: 83 start-page: 472 year: 2013 end-page: 484 article-title: Brain morphometry reproducibility in multicenter 3 T MRI studies: a comparison of cross‐sectional and longitudinal segmentations publication-title: NeuroImage – volume: 138 start-page: 2814 year: 2015 end-page: 2833 article-title: The preclinical phase of the pathological process underlying sporadic Alzheimer's disease publication-title: Brain – volume: 17 start-page: 3749 issue: 1 year: 1982 article-title: Development and validation of a geriatric depression screening scale: a preliminary report publication-title: J Psychiatr Res – volume: 38 year: 2023 article-title: Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer's disease publication-title: NeuroImage Clin – volume: 37 start-page: 3979 issue: 11 year: 2016 end-page: 3998 article-title: In vivo delineation of subdivisions of the human amygdaloid complex in a high‐resolution group template publication-title: Hum Brain Mapp – volume: 156 start-page: 216 issue: 2 year: 1999 end-page: 222 article-title: Amygdalar volume and emotional memory in Alzheimer's disease publication-title: Am J Psychiatry – volume: 792 year: 2023 article-title: The D‐serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer's disease publication-title: Neurosci. Lett. – volume: 77 start-page: 2 issue: 1 year: 2018 end-page: 20 article-title: The amygdala as a locus of pathologic misfolding in neurodegenerative diseases publication-title: J Neuropathol Exp Neurol – volume: 112 start-page: 2 year: 2014 end-page: 16 article-title: How the amygdala affects emotional memory by altering brain network properties publication-title: Neurobiol Learn Mem – volume: 37 start-page: 377 issue: 2 year: 1990 end-page: 385 article-title: Pathological alterations in the amygdala in Alzheimer's disease publication-title: Neuroscience – ident: e_1_2_8_10_1 doi: 10.1016/j.neurobiolaging.2019.07.005 – ident: e_1_2_8_16_1 doi: 10.1002/alz.046762 – volume-title: Wechsler Memory Scale Revised: Manual year: 1987 ident: e_1_2_8_23_1 – ident: e_1_2_8_40_1 doi: 10.1002/hbm.23289 – ident: e_1_2_8_5_1 doi: 10.2174/1567205017666201203085524 – ident: e_1_2_8_4_1 doi: 10.1212/WNL.0000000000005303 – ident: e_1_2_8_8_1 doi: 10.1212/01.wnl.0000336925.79704.9f – ident: e_1_2_8_30_1 doi: 10.1177/0891988719882102 – ident: e_1_2_8_36_1 doi: 10.1002/path.2565 – ident: e_1_2_8_44_1 doi: 10.1002/ana.20100 – volume-title: L'examen clinique en psychologie year: 1964 ident: e_1_2_8_22_1 – ident: e_1_2_8_32_1 doi: 10.1038/s41467-020-15701-2 – ident: e_1_2_8_45_1 doi: 10.1097/NEN.0b013e31816a1df3 – ident: e_1_2_8_43_1 doi: 10.1093/brain/awy132 – ident: e_1_2_8_20_1 doi: 10.1016/0306-4522(90)90408-V – ident: e_1_2_8_41_1 doi: 10.1212/WNL.0b013e31820d62d9 – ident: e_1_2_8_15_1 doi: 10.1016/j.cub.2007.08.005 – ident: e_1_2_8_31_1 doi: 10.1016/00223956(82)900334 – ident: e_1_2_8_38_1 doi: 10.1093/brain/aww243 – ident: e_1_2_8_29_1 doi: 10.1097/00002093-199700112-00003 – ident: e_1_2_8_39_1 doi: 10.1016/j.neurobiolaging.2014.06.032 – ident: e_1_2_8_17_1 doi: 10.1002/hbm.25216 – ident: e_1_2_8_35_1 doi: 10.1176/ajp.156.2.216 – ident: e_1_2_8_33_1 doi: 10.1016/j.pscychresns.2011.06.014 – ident: e_1_2_8_19_1 doi: 10.1002/(SICI)1096-9861(19970324)379:4<482::AID-CNE2>3.0.CO;2-Z – ident: e_1_2_8_9_1 doi: 10.1016/j.jalz.2016.11.006 – ident: e_1_2_8_28_1 doi: 10.1093/geronj/37.3.323 – ident: e_1_2_8_52_1 doi: 10.1016/j.neuroimage.2013.05.007 – ident: e_1_2_8_42_1 doi: 10.1002/jmri.26037 – ident: e_1_2_8_48_1 doi: 10.3233/JAD-220228 – start-page: 39 year: 1989 ident: e_1_2_8_24_1 article-title: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease publication-title: Neurology – ident: e_1_2_8_25_1 doi: 10.1017/S1366728911000332 – ident: e_1_2_8_21_1 doi: 10.1016/j.neuroimage.2017.04.046 – ident: e_1_2_8_34_1 doi: 10.2174/1567205011666140131123653 – ident: e_1_2_8_47_1 doi: 10.1111/bpa.12289 – ident: e_1_2_8_11_1 doi: 10.1016/j.nicl.2023.103374 – volume-title: Compendium of Neuropsychological Tests year: 1998 ident: e_1_2_8_27_1 – ident: e_1_2_8_46_1 doi: 10.1002/cne.23415 – ident: e_1_2_8_51_1 doi: 10.1016/j.nlm.2014.02.005 – ident: e_1_2_8_12_1 doi: 10.1093/jnen/nlx099 – ident: e_1_2_8_37_1 doi: 10.1016/j.neulet.2022.136958 – ident: e_1_2_8_53_1 doi: 10.1016/j.neuroimage.2008.12.033 – ident: e_1_2_8_26_1 doi: 10.1002/gps.3992 – ident: e_1_2_8_18_1 doi: 10.3389/fnagi.2017.00050 – ident: e_1_2_8_50_1 doi: 10.1016/j.nicl.2016.12.011 – ident: e_1_2_8_7_1 doi: 10.1007/s11682-020-00366-8 – ident: e_1_2_8_49_1 doi: 10.1016/j.pscychresns.2006.01.007 – ident: e_1_2_8_2_1 doi: 10.1038/nrneurol.2015.250 – ident: e_1_2_8_13_1 doi: 10.1093/brain/awv236 – ident: e_1_2_8_6_1 doi: 10.1016/j.neurobiolaging.2018.10.004 – ident: e_1_2_8_14_1 doi: 10.1212/WNL.0000000000001171 – volume: 15 year: 2023 ident: e_1_2_8_3_1 article-title: The amyloid cascade hypothesis: an updated critical review publication-title: Brain |
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| Snippet | Introduction
Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether... Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy... IntroductionAccumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether... Abstract Introduction Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still... |
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| SubjectTerms | Alzheimer's disease Alzheimer's disease (AD) Amygdala Cognition & reasoning Dementia Magnetic resonance imaging magnetic resonance imaging (MRI) mild cognitive impairment (MCI) Pathology preclinical subfields |
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| Title | Atrophy of specific amygdala subfields in subjects converting to mild cognitive impairment |
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