Association Study between Novel CYP26 Polymorphisms and the Risk of Betel Quid-Related Malignant Oral Disorders

• Published in: TheScientificWorld Vol. 2015; no. 2015; pp. 1 - 9
• Main Authors: Chen, Ping-Ho, Chien, Pei-Hsuan, Lee, Kun-Tsung, Wang, Yen-Yun, Chen, Chun-Ming, Shieh, Tien-Yu, Chen, Yun-Ju, Wu, Shyh-Jong, Lin, Yueh-Ming
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2015; John Wiley & Sons, Inc; Wiley
• Subjects: Adult; Areca - adverse effects; Cytochrome P-450; Cytochrome P-450 Enzyme System - genetics; Genetic aspects; Genetic Association Studies - methods; Genetic polymorphisms; Health aspects; Hospitals; Humans; Male; Middle Aged; Mouth cancer; Mouth Mucosa - pathology; Mouth Neoplasms - diagnosis; Mouth Neoplasms - etiology; Mouth Neoplasms - genetics; Pharyngeal Neoplasms - diagnosis; Pharyngeal Neoplasms - etiology; Pharyngeal Neoplasms - genetics; Polymorphism, Single Nucleotide - genetics; Retinoic Acid 4-Hydroxylase; Risk Factors; Rodents; Studies; Vitamin A

BQ chewing may produce significant amounts of reactive oxygen species (ROS), resulting in oral mucosa damage, and ROS may be metabolized by CYP26 families. Because the CYP26 polymorphisms associated with malignant oral disorders are not well known, we conducted an association study on the associatio...