Alterations in the Processing of Platelet APP (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus

• Published in: Neuropsychopharmacology reports Vol. 45; no. 1; pp. e12525 - n/a
• Main Authors: Al‐kuraishy, Hayder M., Sulaiman, Ghassan M., Mohammed, Hamdoon A., Dawood, Retaj A., Albuhadily, Ali K., Al‐Gareeb, Ali I., Abomughaid, Mosleh M., Klionsky, Daniel J.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2025; John Wiley and Sons Inc; Wiley
• Subjects: activated platelets; Alzheimer Disease - blood; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-Protein Precursor - metabolism; amyloid precursor protein; Amyloid Precursor Protein Secretases - metabolism; Animals; Blood platelets; Blood Platelets - metabolism; Cognitive ability; Cytokines; Dementia; Homeostasis; Humans; Immunity (Disease); Ligands; Metabolism; Nervous system; Neurodegeneration; Neuropathology; Oxidative stress; Pathogenesis; Peptides; Physiology; Platelet Activation - physiology; Proteins; Review; pathogenesis; activated platelets; amyloid precursor protein; Alzheimer's disease

ABSTRACT Alzheimer's disease (AD) is the most common neurodegenerative disease associated with the development of dementia. The hallmarks of AD neuropathology are accumulations of amyloid peptide (Aβ) and neurofibrillary tangles (NFTs). Aβ is derived from the processing of APP (amyloid beta pre...